Rat TNF R1 ELISA Kit/大鼠TNF R1 ELISA试剂盒
货号：ERA55RB,ERA55RBX5
规格：96 Tests,5X96 Tests
价格：6641,29884
产品类型：Platinum ELISA
品牌：Thermo Fisher
物种：大鼠
宿主：其它
抗体亚型：其它
荧光染料：其它
灵敏度 | 2 pg/mL |
| 检测范围 | 2-600 pg/mL |
样本类型/体积 | 血清 50 μL 血浆 50 μL 上清液 50 μL |
操作时间 | 1 hr 20 min |
测试时间 | 4 hr 45 min |
Homogenous (no wash) | No |
| 批间变异系数（CV） | <12% |
| 批内变异系数（CV） | <10% |
仪器设备 | Colorimetric Microplate Reader 酶标仪 |
规格 | 5 x 96 Tests |
组份 | - 预包被96孔板 - 标准品 - 测定稀释浓缩液 - 生物素化检测抗体 - SAV-HRP - 洗涤液 - 显色剂 - 终止液 - 胶板盖 |
储存温度 | 2-8℃ |
| Protein name | TNFR1 |
| Protein aliases | CD120a, p55, p60, TNF-R1, TNF-RI, TNFR-I, Tumor necrosis factor receptor 1, Tumor necrosis factor receptor superfamily member 1A, Tumor necrosis factor receptor type I |
物种（Tested） | 大鼠 |
试剂盒类型 | Sandwich ELISA Kit |
标记（染料） | HRP |
| 检测抗体偶联物 | Biotin |
| Gene aliases | TNFR-1, Tnfr1, Tnfrsf1a |
| Gene ID | (Rat) 25625 |
| Gene symbol | Tnfrsf1a |
| UniProt ID | (Rat) P22934 |
| Rat TNF R1 quantitates rat TNF R1 in serum, plasma, supernatant. The assay will exclusively recognize both natural and recombinant rat TNF R1.大鼠TNF R1定量测定血清，血浆，上清液中的大鼠TNF R1。该检测试剂盒将专门识别天然和重组大鼠TNF R1。Target information 靶标信息TNFR1 (Tumor necrosis factor receptor 1) belongs to the tumor necrosis factor superfamily, and is one of the major TNF-alpha receptors. TNFR1 plays an important role in mediating, in cytokine mediated signaling, positive regulation of the NF-Kb pathway, positive regulation of angiogenesis, and negative regulation of gene expression. The extracellular domain of TNFR1 is also released into the circulatory system as soluble TNFR1 (sTNFR1). In humans, the TNFR1 gene is located on chromosome 12. Anti-apoptotic protein BCL2-associated athanogene 4 (BAG4/SODD) and adaptor proteins TRADD and TRAF2 have been shown to interact with TNFR1, and thus play regulatory roles in the signal transduction mediated by the receptor. Germline mutations of the extracellular domains of TNFR1 were found to be associated with the autosomal dominant periodic fever syndrome, and the impaired receptor clearance is thought to be a mechanism of the disease.TNFR1（肿瘤坏死因子受体1）属于肿瘤坏死因子超家族，并且是主要的TNF-α受体之一。 TNFR1在介导细胞因子介导的信号传导，NF-Kb途径的正调控，血管生成的正调控和基因表达的负调控中起着重要作用。 TNFR1的胞外域也作为可溶性TNFR1（sTNFR1）释放到循环系统中。在人类中，TNFR1基因位于12号染色体上。抗凋亡蛋白BCL2相关的致癌基因4（BAG4 / SODD）和衔接蛋白TRADD和TRAF2已显示与TNFR1相互作用，因此在介导的信号转导中起调节作用通过受体。发现TNFR1胞外域的种系突变与常染色体显性周期性发热综合征有关，并且受体清除受损被认为是该疾病的一种机制。For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.仅供研究使用。 不用于诊断过程。 未经明确授权不得转售。 |
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