CD45.2 Monoclonal Antibody (104), PerCP-Cyanine5.5
货号： 45-0454-82,45-0454-80
规格：100μg,25μg
价格：3035,925
产品类型：流式抗体
品牌：Thermo Fisher
物种：小鼠
宿主：小鼠
抗体亚型：IgG
克隆号：104
荧光染料：PerCP-Cy5.5
抗体类型: | 单抗 | 同型对照： | Mouse IgG2a kappa Isotype Control, PerCP-Cyanine5.5, eBioscience™ |
免疫原性： | | 用法： | 1 µg/test(Flow） |
Description: The 104 monoclonal antibody reacts with the mouse CD45 molecule, the leukocyte common antigen (LCA) in CD45.2-expressing mouse strains. The strains that express CD45.2 include the most commonly used mouse strains C57BL/6, BALB/c, C58, DBA/1, DBA/2, C3H/He, CBA, 129, A and AKR. CD45.2 is expressed by all leukocytes in these strains.Applications Reported: This 104 antibody has been reported for use in flow cytometric analysis.Applications Tested: This 104 antibody has been tested by flow cytometric analysis of BALB/c splenocytes. This can be used at less than or equal to 1 µg per test. A test is defined as the amount (µg) of antibody that will stain a cell sample in a final volume of 100 µL. Cell number should be determined empirically but can range from 10^5 to 10^8 cells/test. It is recommended that the antibody be carefully titrated for optimal performance in the assay of interest.Excitation: 488 nm; Emission: 695 nm; Laser: Blue Laser.Filtration: 0.2 µm post-manufacturing filtered.Background/Target InformationCD45.2 (LCA, leukocyte common antigen) is a receptor-type protein tyrosine phosphatase ubiquitously expressed in all nucleated hematopoietic cells, comprising approximately 10% of all surface proteins in lymphocytes. CD45.2 glycoprotein is crucial in lymphocyte development and antigen signaling, serving as an important regulator of Src-family kinases. CD45.2 protein exists as multiple isoforms as a result of alternative splicing; these isoforms differ in their extracellular domains, whereas they share identical transmembrane and cytoplasmic domains. These isoforms differ in their ability to translocate into the glycosphingolipid-enriched membrane domains and their expression depends on cell type and physiological state of the cell. Besides the role in immunoreceptor signaling, CD45.2 is important in promoting cell survival by modulating integrin-mediated signal transduction pathway and is also involved in DNA fragmentation during apoptosis. CD45RA is an isoform of the CD45 complex and has restricted expression between different subtypes of lymphoid cells.For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
数据 |
| CD45.2 Antibody (45-0454-82) in Flow Staining of BALB/c splenocytes with 0.5 µg of Mouse IgG2a K Isotype Control PerCP-Cyanine5.5 (Product # 45-4724-82) (open histogram) or 0.5 µg of Anti-Mouse CD45.2 PerCP-Cyanine5.5 (filled histogram). Cells in the lymphocyte gate were used for analysis |
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参考文献： |
| 1. EBioMedicineDendritic Cells Aggravates Atherosclerosis via Th1 Cell Induction and Enhanced CCL5 Expression in Plaque Macrophages.By clicking the link above, you will be redirected to the Benchsci website.Disclaimer2. The Journal of experimental medicineEgr2 and 3 control adaptive immune responses by temporally uncoupling expansion from T cell differentiation. By clicking the link above, you will be redirected to the Benchsci website.Disclaimer3. Nature communicationsIntratumoral modulation of the inducible co-stimulator ICOS by recombinant oncolytic virus promotes systemic anti-tumour immunity.By clicking the link above, you will be redirected to the Benchsci website.Disclaimer4. Cell reportsPneumocystis-Driven Inducible Bronchus-Associated Lymphoid Tissue Formation Requires Th2 and Th17 Immunity.By clicking the link above, you will be redirected to the Benchsci website.Disclaimer5. Stem cell reportsMurine iPSC-Derived Macrophages as a Tool for Disease Modeling of Hereditary Pulmonary Alveolar Proteinosis due to Csf2rb Deficiency.By clicking the link above, you will be redirected to the Benchsci website.Disclaimer |
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