HP1 alpha Polyclonal Antibody

货号：PA5-82556

规格：100 µL

价格：5816

产品类型：标签抗体

品牌：Thermo Fisher

抗原： Recombinant protein corresponding to Human CBX5

物种：人

宿主：兔

抗体亚型：IgG

荧光染料：其它

类型:	一抗	同型对照：
浓度：	0.10 mg/mL	用法：	1:200-1:500（IHC(P)）；0.25-2 µg/mL（ICC）；0.25-2 µg/mL(IF);0.04-0.4 µg/mL(WB）

产品详细信息Immunogen sequence: VVKGQVEYLL KWKGFSEEHN TWEPEKNLDC PELISEFMKK YKKMKEGENN KPREKSESNK RKSNFSNSAD DIKSKKKREQ SNDIARGFER GLEPEKIIGA TDSCGDLM靶标信息Heterochromatin protein-1 (HP1) is a methyl-lysine binding protein localized at heterochromatin sites, where it mediates gene silencing. It has been shown that mammalian methyltransferases that selectively methylate histone H3 on lysine-9 generate a binding site for HP1 proteins, a family of heterochromatic adaptor molecules implicated in both gene silencing and supranucleosomal chromatin structure. High-affinity in vitro recognition of a methylated histone H3 peptide by HP1 requires a functional chromodomain. Thus, the HP1 chromodomain is a specific interaction motif for the methyl epitope on lysine-9 of histone H3. In vivo, heterochromatin association of HP1 proteins is lost in Suv39h double-null primary mouse fibroblasts but is restored after reintroduction of a catalytically active SUV39H1 HMTase.

数据：

HP1 alpha Antibody (PA5-82556) in IFImmunofluorescent analysis of HP1 alpha in U-2 OS cells using a HP1 alpha polyclonal antibody (Product # PA5-82556). The analysis shows localization to nucleus. HP1 alpha Antibody (PA5-82556) in IHCImmunohistochemical analysis of HP1 alpha in human parathyroid gland using a HP1 alpha polyclonal antibody (Product # PA5-82556). The analysis shows moderate to strong nuclear positivity in chief cells.

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技术参数

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