Mouse Clusterin ELISA /小鼠Clusterin ELISA试剂盒
货号：EM18RB,EM18RBX5,EM18RBX10
规格：96 Tests,5X96 Tests,10X96 tests
价格：6641,29884,57271
产品类型：Platinum ELISA
品牌：Thermo Fisher
物种：小鼠
宿主：其它
抗体亚型：其它
荧光染料：其它
灵敏度 | 0.1 ng/mL |
| 检测范围 | 0.1-24 ng/mL |
样本类型/体积 | 血清 50 μL 血浆 50 μL 上清液 50 μL |
操作时间 | 1 hr 20 min |
测试时间 | 4 hr 45 min |
Homogenous (no wash) | No |
| 批间变异系数（CV） | <12% |
| 批内变异系数（CV） | <10% |
仪器设备 | Colorimetric Microplate Reader 酶标仪 |
规格 | 5 x 96 Tests |
组份 | - 预包被96孔板 - 标准品 - 测定稀释浓缩液 - 生物素化检测抗体 - SAV-HRP - 洗涤液 - 显色剂 - 终止液 - 胶板盖 |
储存温度 | 2-8℃ |
| Protein name | Apolipoprotein J |
| Protein aliases | Apo-J, Apolipoprotein J, Clusterin, Clusterin alpha chain, Clusterin beta chain, Clustrin, complement lysis inhibitor, SGP-2, Sulfated glycoprotein 2, testosterone repressed prostate message, testosterone repressed prostate message-2 |
物种（Tested） | 小鼠 |
试剂盒类型 | Sandwich ELISA Kit |
标记（染料） | HRP |
| 检测抗体偶联物 | Biotin |
| Gene aliases | AI893575, ApoJ, Cli, Clu, D14Ucla3, Msgp-2, Sgp-2, Sgp2, SP-40, Sugp-2 |
| Gene ID | (Mouse) 12759 |
| Gene symbol | Clu |
| UniProt ID | (Mouse) Q06890 |
| Mouse Clusterin quantitates mouse Clusterin in serum, plasma, supernatant. The assay will exclusively recognize both natural and recombinant mouse Clusterin.小鼠Clusterin定量分析血清，血浆，上清液中的小鼠Clusterin。该检测试剂盒将专门识别天然和重组小鼠Clusterin。Target information 靶标信息Isoform 1 functions as extracellular chaperone that prevents aggregation of nonnative proteins. Prevents stress-induced aggregation of blood plasma proteins. Inhibits formation of amyloid fibrils by APP, APOC2, B2M, CALCA, CSN3, SNCA and aggregation-prone LYZ variants (in vitro). Does not require ATP. Maintains partially unfolded proteins in a state appropriate for subsequent refolding by other chaperones, such as HSPA8/HSC70. Does not refold proteins by itself. Binding to cell surface receptors triggers internalization of the chaperone-client complex and subsequent lysosomal or proteasomal degradation. Secreted isoform 1 protects cells against apoptosis and against cytolysis by complement. Intracellular isoforms interact with ubiquitin and SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complexes and promote the ubiquitination and subsequent proteasomal degradation of target proteins. Promotes proteasomal degradation of COMMD1 and IKBKB. Modulates NF-kappa-B transcriptional activity. Nuclear isoforms promote apoptosis. Mitochondrial isoforms suppress BAX-dependent release of cytochrome c into the cytoplasm and inhibit apoptosis. Plays a role in the regulation of cell proliferation.Isoform 1充当防止非天然蛋白聚集的细胞外分子伴侣。防止压力诱导的血浆蛋白聚集。抑制APP，APOC2，B2M，CALCA，CSN3，SNCA和易聚集的LYZ变体（体外）形成淀粉样蛋白原纤维。不需要ATP。将部分未折叠的蛋白质保持在适合随后被其他伴侣（例如HSPA8 / HSC70）重折叠的状态。自身不折叠蛋白质。与细胞表面受体的结合触发伴侣-客户复合物的内在化和随后的溶酶体或蛋白酶体降解。分泌的同工型1通过补体保护细胞免于凋亡和细胞溶解。细胞内同工型与遍在蛋白和SCF（SKP1-CUL1-F-box蛋白）E3遍在蛋白-蛋白连接酶复合物相互作用，并促进遍在蛋白化和随后蛋白酶体降解靶蛋白。促进COMMD1和IKBKB的蛋白酶体降解。调节NF-κB的转录活性。核亚型促进细胞凋亡。线粒体同工型抑制BAX依赖的细胞色素c释放到细胞质中并抑制细胞凋亡。在细胞增殖的调节中起作用。For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.仅供研究使用。 不用于诊断过程。 未经明确授权不得转售。 |
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