GadoSpin D/MRI造影剂
货号：130-095-164,130-095-165
规格：for 5 injections ,for 5×5 injections
价格：0,0
产品类型：小动物造影剂
品牌：Miltenyi
| GadoSpin D is a dendritic gadolinium-based contrast agent of intermediate molecular weight specifically formulated for preclinical magnetic resonance imaging (MRI).It is a contrast agent of high relaxivity increasing the signal intensity in T1-weighted MRI due to a shortening of the spin-lattice relaxation time (T1).Upon intravenous injection, GadoSpin D remains within the vascular system. Significant extravasation can be observed in fenestrated blood vessels of inflamed tissue or tumors.GadoSpin D is mainly excreted via glomerular filtration (kidneys).ApplicationsGadoSpin D is indicated for use in MRI of small animals, for example, mice, to facilitate the visualization of the vasculature.Examples include dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI), tumor characterization and therapy monitoring.GadoSpin D是一种独特的树枝状MRI 造影剂，用于研究肿瘤或炎症组织中血管完整性，其完整的球状结构含有24 个钆离子。GadoSpinD是一种树突状钆鳌合中间分子量造影剂，专门用于临床前磁共振成像(MRI)。它是一种高度放松的造影剂，由于spin-lattice relaxation time (T1)的缩短，GadoSpin F在T1-weighted MRI中增加了信号强度。静脉注射后，GadoSpinD仍在血管系统内。 在发炎组织或肿瘤的破裂血管中可以观察到明显的外渗。GadoSpinD主要通过肾小球滤过（肾脏)排出。应用Gado Spin D被用于小动物的MRI，例如小鼠，以促进血管的可视化。例如动态增强磁共振成像(DCE-MRI)、肿瘤特征和治疗监测。 |
优点： |
| -涵盖全面，应用范围广；- 操作简单； - 高效。 |
数据： |
图1.GadoSpin D原理图 |
组成成分： |
| ▪850 µL GadoSpin™ D, MRI contrast agent (dendritic Gd-chelate) or 5×850 µL GadoSpin™ D, MRI contrast agent (dendritic Gd-chelate) |
相关产品： |
| ▪ExiTron V二聚化非离子胞外CT造影剂（货号#130-095-283）▪ExiTron P CT 肾排泄血管造影剂（货号#130-095-144）▪ExiTron nano 6000 肝脏显像CT 造影剂（货号#130-095-146）▪ExiTron nano 12000CT 血管造影剂（货号#130-095-698）▪GadoSpin F动脉粥样硬化成像剂MRI 造影剂（货号#130-095-162）▪GadoSpin P MR 血管造影剂（货号#130-095-136）▪GadoSpin D动态造影增强MRI 造影剂（货号#130-095-164）▪GadoSpin M 胞外MRI 造影剂（货号#130-095-134）▪FeraSpin R 肝脏显像MRI 造影剂（货号#130-095-138）▪FeraSpin XS 纳米微粒血管MRI 造影剂（货号#130-095-140）▪FeraSpin S 纳米微粒（货号#130-095-166）▪FeraSpin M纳米微粒血管MRI 造影剂（货号#130-095-168）▪FeraSpinL纳米微粒血管MRI 造影剂（货号#130-095-170）▪PolySon H超声微泡（货号#130-095-152）▪PolySon L hard-shell 超声微泡（货号#130-095-150）▪NiraWave C 光学显像造影剂（货号#130-095-154）▪NiraWave M 光学炎症显像造影剂（货号#130-095-157）▪NiraWave nano 780 光学血管造影剂（货号#130-095-693） |
| 参考文献 |
| 1. Su, M. Y. et al. (2002) Measurement of volumetric and vascular changes with dynamic contrast enhanced MRI for cancer therapy monitoring. Technol. Cancer Res. Treat. 1: 479-4882. Verhoye, M. et al. (2002) Assessment of the neovascular permeability in glioma xenografts by dynamic T(1) MRI with Gadomer-17. Magn. Reson. Med. 47: 305-3133. Fink, C. et al. (2003) High-resolution three-dimensional MR angiography of rodent tumors: morphologic characterization of intratumoral vasculature. J. Magn. Reson. Imaging 18: 59-654. Hamzah, J. et al. (2008) Vascular normalization in Rgs5-deficient tumours promotes immune destruction. Nature 453: 410-414 |
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