TGF beta-1,2,3 Monoclonal Antibody (1D11.16.8), Functional Grade, eBioscience™/TGF beta-1,2,3 单克隆 (1D11.16.8), 功能抗体, eBioscience™

货号：16-9243-85,16-9243-38,16-9243-025,16-9243-050

规格：500 µg,5 mg,25 mg,50 mg

价格：5016,24089,72266,120443

产品类型：流式抗体

品牌：eBioscience

抗原：TGF beta-1,2,3

物种：人/小鼠

宿主：小鼠

抗体亚型：其它

克隆号：1D11.16.8

荧光染料：其它

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类型:	一抗(功能抗体）	同型对照：	IgG1
浓度：	1 mg/mL	用法：	Assay-Dependent（中和）；Assay-Dependent（功能检测）

产品详细信息Description: The monoclonal antibody 1D11.16.8 recognizes human, mouse, rat, hamster, canine and non-human primate Transforming Growth Factor (TGF) beta 1, 2 and 3. TGF beta is a pleiotropic cytokine that exists as five isoforms (TGF beta 1-5) that share 70-80% homology with each other. However, these isoforms are not homologous to TGF alpha. TGF beta 1 is highly conserved between human, murine, simian, bovine, porcine, and chicken proteins. TGF beta 1 is the most abundant isoform and is ubiquitously expressed by a variety of cell types, including platelets, macrophages, lymphocytes, endothelial cells, chondrocytes, and leukemic cells. However, the other isoforms exhibit a more restricted expression pattern.TGF beta 1 is synthesized as a long precursor polypeptide, which is cleaved to yield the mature protein and the Latency Associated Peptide (LAP). LAP and mature TGF beta 1 remain non-covalently associated during secretion, forming homodimers known as the Small Latent Complex (SLC). Secretion can be induced by steroids, retinoids, EGF, NGF, vitamin D3, and IL-1. The bioactivity of mature TGF beta 1 is dependent on its release from LAP by conformational changes and proteolytic processing. Its activities include inhibition of cell growth in epithelial cells, endothelial cells, fibroblasts, neurons, lymphoid cells, and other hematopoietic cell types. TGF beta 1 also inhibits the proliferation of T and NK cells, downregulates the activities of activated macrophages, and blocks the anti-tumor activity of IL-2 - bearing lymphokine-activated killer (LAK) cells. Recently, TGF beta 1 has been found to play a critical role in the development of regulatory T cells and act as a costimulatory factor for expression of Foxp3. Dendritic cells exposed to tumors have been reported to secrete TGF beta 1 and stimulate the differntiation of CD4+CD25+ Treg cell from peripheral CD4+CD25- progeny. TGF beta 1-induced regulatory T cells have been termed iTregs.Applications Reported: This 1D11.16.8 antibody has been reported for use in neutralization assays both in vivo and in vitro and immunohistochemical staining of formalin-fixed paraffin embedded tissue sections.Storage and handling: Use in a sterile environment.Filtration: 0.2 µm post-manufacturing filtered.Purity: Greater than 90%, as determined by SDS-PAGE.Endotoxin Level: Less than 0.001 ng/µg antibody, as determined by LAL assay.Aggregation: Less than 10%, as determined by HPLC.靶标信息TGF-beta1, -2, and -3 are a closely related group of proteins (70-80% sequence homology) that are produced by many cell types and function as growth and differentiation factors. The active forms of TGF-beta1, -2, and -3 are disulfide-linked homodimers.仅用于科研。不用于诊断过程。

数据

TGF beta-1,2,3 Antibody (16-9243-85)Oncoimmunology 2016 -Published figure using TGF beta-1,2,3 monoclonal antibody (Product # 16-9243-85)

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参考文献：

中和1.PloS oneCholera Toxin Promotes Th17 Cell Differentiation by Modulating Expression of Polarizing Cytokines and the Antigen-Presenting Potential of Dendritic Cells."16-9243 was used in Neutralization experiments to determine how cholera toxin skews the differentiation of CD4 T cells to form IL-17-producing Th17 cells."AuthorsKang JO,Lee JB,Chang J2.OncoimmunologyWarburg metabolism in tumor-conditioned macrophages promotes metastasis in human pancreatic ductal adenocarcinoma."Published figure using TGF beta-1,2,3 monoclonal antibody (Product # 16-9243-85) in Neutralization"

技术参数

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