CD124 Monoclonal Antibody (X2/45-12), Functional Grade, eBioscience™/CD124 单克隆 (X2/45-12), 功能抗体, eBioscience™
货号：16-1249-82,16-1249-025,16-1249-050
规格：100 µg,25 mg,50 mg
价格：2684,72266,120443
产品类型：流式抗体
品牌：eBioscience
抗原：CD124
物种：人
宿主：小鼠
抗体亚型：IgG1, kappa
克隆号：X2/45-12
荧光染料：其它
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类型: | 一抗(功能抗体） | 同型对照： | Mouse IgG1 kappa Isotype Control (P3.6.2.8.1), Functional Grade, eBioscience™ |
浓度： | 1 mg/mL | 用法： | 1 µg/test（Flow）;Assay-Dependent（功能检测） |
产品详细信息Description: The X2/45-12 monoclonal antibody reacts with the human IL-4 receptor alpha chain. IL-4 receptor alpha chain (CD124) is crucial for the binding and signal transduction of IL-4. Both IL-4 and IL-13 use the IL-4 receptor alpha chain as their receptor component and activate many common signal pathways.Applications Reported: X2/45-12 has been reported for use in flow cytometric analysis. X2/45-12 has also been reported in neutralization of human IL-4 function.Applications Tested: The X2/45-12 antibody has been tested by flow cytometric analysis of normal human peripheral blood cells. This can be used at less than or equal to 1 µg per test. A test is defined as the amount (µg) of antibody that will stain a cell sample in a final volume of 100 µL. Cell number should be determined empirically but can range from 10^5 to 10^8 cells/test. It is recommended that the antibody be carefully titrated for optimal performance in the assay of interest.Storage and handling: Use in a sterile environment.Filtration: 0.2 µm post-manufacturing filtered.Purity: Greater than 90%, as determined by SDS-PAGE.Endotoxin Level: Less than 0.001 ng/µg antibody, as determined by LAL assay.Aggregation: Less than 10%, as determined by HPLC.靶标信息IL4 Receptor alpha (IL4RA) is the alpha chain of the interleukin 4 receptor which binds to both interleukin 4 and interleukin 13 to regulate IgE production, chemokine and mucus production at sites of allergic inflammmation. The IL4 response is involved in promoting Th2 differentiation. The secreted extracellular domain of IL4R alpha, called sIL4R alpha, can inhibit IL4-mediated cell proliferation and IL5 upregulation by T-cells. It has no signaling abilities. Allelic variations in the IL4RA genehave been associated with atopy, a condition that can manifest itself as allergic rhinitis, sinusitus, asthma, or eczema.仅用于科研。不用于诊断过程。
数据 |
| CD124 Antibody (16-1249-82) in FlowSurface staining of normal human peripheral blood cells with Anti-Human CD124 Purified followed by Anti-Mouse IgG Biotin and Streptavidin PE (Product # 12-4317-87). Appropriate isotype controls were used (open histogram). Cells in the lymphocyte population were used for analysis. |
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