CD49b (Integrin alpha 2) Monoclonal Antibody (HMa2), Functional Grade, eBioscience™/CD49b (Integrin alpha 2) 单克隆 (HMa2), 功能抗体, eBioscience™

货号：16-0491-81,16-0491-85,16-0491-38,16-0491-025,16-0491-050

规格：50 µg,500 µg,5 mg,25 mg,50 mg

价格：1156,3496,24089,72266,120443

产品类型：流式抗体

品牌：eBioscience

抗原：CD49b

物种：小鼠

宿主：Armenian hamster仓鼠

抗体亚型：IgG

克隆号：HMa2

荧光染料：其它

_ueditor_page_break_tag_

类型:	一抗(功能抗体）	同型对照：	Armenian Hamster IgG Isotype Control (eBio299Arm), Functional Grade, eBioscience™
浓度：	1 mg/mL	用法：	0.5 µg/test（Flow）;Assay-Dependent（功能检测）

产品详细信息Description: The HMalpha2 monoclonal antibody reacts with mouse CD49b, the 150 kDa integrin alpha2 subunit. The complex of CD49b non-covalently associated with integrin beta1 (CD29), also known as VLA-2, is a receptor for collagen and laminin. This complex is expressed by some CD4^+ T cells, IEL, NK cells, platelets and epithelial cells.Applications Reported: The HM alpha2 antibody has been reported for use in flow cytometric analysis. It has also been reported for use in in vitro functional assays.Applications Tested: The HM alpha2 antibody has been tested by flow cytometric analysis of mouse splenocytes. This can be used at less than or equal to 0.5 µg per test. A test is defined as the amount (µg) of antibody that will stain a cell sample in a final volume of 100 µL. Cell number should be determined empirically but can range from 10^5 to 10^8 cells/test. It is recommended that the antibody be carefully titrated for optimal performance in the assay of interest.Storage and handling: Use in a sterile environment.Filtration: 0.2 µm post-manufacturing filtered.Purity: Greater than 90%, as determined by SDS-PAGE.Endotoxin Level: Less than 0.001 ng/µg antibody, as determined by LAL assay.Aggregation: Less than 10%, as determined by HPLC.靶标信息CD49b (Integrin alpha 2, Integrin alpha 2 chain, VLA-2 alpha chain, HM alpha 2) is a member of the integrin family. It is a glycoprotein with molecular weight of 150 kD, and it complexes with CD29 (Integrin beta 1) to form the heterodimeric integrin VLA-2 (integrin alpha 2 beta 1, or GPIa/IIa) complex. VLA-2 is an extracellular receptor for laminin, collagen, and fibronectin, and interaction with its ligands results in the activation of intracellular signaling pathways. It has reported roles inVEGF-induced angiogenesis in vivo, as well as adhesion and lymphocyte activation. CD49b is expressed by NK cells, NK-T cells, monocytes, platelets, and epithelial cells. It is also expressed on adaptive immune cells such as T and B cells, specifically on a subset of CD4+ T cells in the spleen, on intraepithelial and lamina propria lymphocytes in the intestine, as well as on a population of peripheral CD4+ type 1 T regulatory (Tr1) cells that co-express LAG-3.仅用于科研。不用于诊断过程。

数据

CD49b (Integrin alpha 2) Antibody (16-0491-81) in FlowStaining of mouse splenocytes with Anti-Mouse CD49b (Integrin alpha 2) FITC. Appropriate isotype controls were used (open histogram). Total viable cells were used for analysis.

推荐产品：

二抗荧光二抗免疫组化一抗标签抗体

参考文献：

流式1.Journal of cellular and molecular medicineCytochrome P450 26A1 modulates natural killer cells in mouse early pregnancy."Published figure using CD49b (Integrin alpha 2) monoclonal antibody (Product # 16-0491-81) in Flow Cytometry"2.Cellular and molecular immunologyThe breast tumor microenvironment alters the phenotype and function of natural killer cells."Published figure using CD49b (Integrin alpha 2) monoclonal antibody (Product # 16-0491-81) in Flow Cytometry"3.Cancer researchMigratory and antigen presentation functions of IFN-producing killer dendritic cells."16-0491 was used in Flow cytometry/Cell sorting to study how BM-IKDCs are capable of cytotoxic killing of tumour targets, and also of potent antigen presentation after encountering antigen in the context of a viable target cell."AuthorsHimoudi N,Yan M,Bouma G,Morgenstern D,Wallace R,Seddon B,Buddle J,Eddaoudi A,Howe SJ,Cooper N,Anderson JWB4. Journal of cellular and molecular medicineCytochrome P450 26A1 modulates natural killer cells in mouse early pregnancy."Published figure using CD49b (Integrin alpha 2) monoclonal antibody (Product # 16-0491-81) in Flow Cytometry"

技术参数

© Bio-Rad伯乐代理官网-伯乐抗体-伯乐层析Aminex色谱柱是专业的授权总代理区域代理经销平台。
© 如需询价，请加客服QQ：1749072012 、客服微信：jinshanbio，或发送邮件到1749072012@qq.com
© 平台为生命科学研究相关领域提供一站式耗材试剂仪器解决方案和采购服务，数据资源基于CC协议。
© 本文地址：https://biorod.cn/thread-26434.htm