CD32 Monoclonal Antibody (6C4 (CD32)), Functional Grade, eBioscience™/CD32单克隆(6C4 (CD32)), 功能抗体, eBioscience™

货号：16-0329-81,16-0329-85,16-0329-38,16-0329-025,16-0329-050

规格：50 µg,500 µg,5 mg,25 mg,50 mg

价格：1283,4085,24089,72266,120443

产品类型：流式抗体

品牌：eBioscience

抗原：CD32

物种：人

宿主：小鼠

抗体亚型：IgG1, kappa

克隆号：6C4 (CD32)

荧光染料：其它

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类型:	一抗(功能抗体）	同型对照：	Mouse IgG1 kappa Isotype Control (P3.6.2.8.1), Functional Grade, eBioscience™
浓度：	1 mg/mL	用法：	1 µg/test（Flow）;Assay-Dependent（功能检测）

产品详细信息Description: This 6C4 monoclonal antibody reacts with human CD32 (also known as Fc gammaRII). This antibody recognizes two isoforms of the receptor, Fc gammaRIIA and Fc gammaRIIB. These 40-kDa polymorphic transmembrane glycoproteins are expressed on B cells, granulocytes, monocytes, macrophages, and platelets. Moreover, these receptors are detected on natural killer cells. CD32 enables interaction between Fc gammaRII-expressing cells and opsonized antigen or IgG-containing immune complexes. Bothreceptors exhibit low affinity towards IgG and play a role in inflammation and autoimmune disease. This clone has been reported to inhibit Ig binding in a rosette blocking assay.Applications Tested: This 6C4 (CD32) antibody has been tested by flow cytometric analysis of normal human peripheral blood cells. This can be used at less than or equal to 1 µg per test. A test is defined as the amount (µg) of antibody that will stain a cell sample in a final volume of 100 µL. Cell number should be determined empirically but can range from 10^5 to 10^8 cells/test. It is recommended that the antibody be carefully titrated for optimal performance in the assay of interest.Storage and handling: Use in a sterile environment.Filtration: 0.2 µm post-manufacturing filtered.Purity: Greater than 90%, as determined by SDS-PAGE.Endotoxin Level: Less than 0.001 ng/µg antibody, as determined by LAL assay.Aggregation: Less than 10%, as determined by HPLC.靶标信息This gene encodes one member of a family of immunoglobulin Fc receptor genes found on the surface of many immune response cells. The protein encoded by this gene is a cell surface receptor found on phagocytic cells such as macrophages and neutrophils, and is involved in the process of phagocytosis and clearing of immune complexes. Alternative splicing results in multiple transcript variants.仅用于科研。不用于诊断过程。

数据

CD32 Antibody (16-0329-85) in FlowStaining of normal human peripheral blood cells with Anti-Human CD19 APC (Product # 17-0199-42) and 0.5 µg of Mouse IgG1 K Isotype Control Functional Grade Purified (Product # 16-4714-82) (left) or 0.5 µg of Anti-Human CD32 Functional Grade Purified (right) followed by F (ab')2 Anti-Mouse IgG PE (Product # 12-4010-82).Cells in the lymphocyte gate were used for analysis.

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参考文献：

阻断1.BMC immunologyC-reactive protein (CRP) but not the related pentraxins serum amyloid P and PTX3 inhibits the proliferation and induces apoptosis of the leukemia cell line Mono Mac 6.AuthorsChen W,Pilling D,Gomer RH2.Proceedings of the National Academy of Sciences of the United States of AmericaLatently and uninfected healthcare workers exposed to TB make protective antibodies againstMycobacterium tuberculosis.AuthorsLi H,Wang XX,Wang B,Fu L,Liu G,Lu Y,Cao M,Huang H,Javid B流式3.Journal of neurovirologyImmortalization of primary microglia: a new platform to study HIV regulation in the central nervous system."Published figure using CD32 monoclonal antibody (Product # 16-0329-81) in Flow Cytometry"4.mAbsRecombinant H22(scFv) blocks CD64 and prevents the capture of anti-TNF monoclonal antibody. A potential strategy to enhance anti-TNF therapy."16-0329 was used in Flow cytometry/Cell sorting to demonstrate the specific blocking of CD64 by H22(scFv) could be used as a mechanism for potentiating the effect of anti-TNF antibodies."AuthorsHristodorov D,Mladenov R,Brehm H,Fischer R,Barth S,Thepen TIHC5.PloS oneMechanisms controlling the effects of bevacizumab (avastin) on the inhibition of early but not late formed corneal neovascularization."Published figure using CD32 monoclonal antibody (Product # 16-0329-81) in Immunohistochemistry"

技术参数

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