CD62L (L-Selectin) Monoclonal Antibody (DREG-56 (DREG56)), Functional Grade, eBioscience™/CD62L (L-Selectin) 单克隆 (DREG-56 (DREG56)), 功能抗体, eBioscience™

货号：16-0629-85,16-0629-025,16-0629-050

规格：500 µg,25 mg,50 mg

价格：4085,72266,120443

产品类型：流式抗体

品牌：eBioscience

抗原：CD62L

物种：人

宿主：小鼠

抗体亚型：IgG1, kappa

克隆号：DREG-56 (DREG56)

荧光染料：其它

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类型:	一抗(功能抗体）	同型对照：	Mouse IgG1 kappa Isotype Control (P3.6.2.8.1), Functional Grade, eBioscience™
浓度：	1 mg/mL	用法：	1 µg/test（Flow）;Assay-Dependent（中和）;Assay-Dependent（功能检测）

产品详细信息Description: The DREG-56 monoclonal antibody reacts with human CD62L, a 76 kDa member of the selectin family. CD62L is expressed by neutrophils, monocytes, and subsets of T, B, and NK cells and binds a number of glycosylated, fucosylated, sulfated sialylated glycoproteins including CD34, glycam-1 and MAdCAM-1. These interactions mediate rolling of lymphocytes on activated endothelium at the sites of inflammation and homing of cells to the high endothelial venules (HEV) of peripheral lymphoid tissues.Applications Reported: The DREG-56 (DREG56) antibody has been reported for use in flow cytometric analysis. DREG-56 has also been reported in inhibition of binding to HEV.Applications Tested: The DREG-56 (DREG56) antibody has been tested by flow cytometric analysis of normal human peripheral blood cells. This can be used at less than or equal to 1 µg per test. A test is defined as the amount (µg) of antibody that will stain a cell sample in a final volume of 100 µL. Cell number should be determined empirically but can range from 10^5 to 10^8 cells/test. It is recommended that the antibody be carefully titrated for optimal performance in the assay of interest.Storage and handling: Use in a sterile environment.Filtration: 0.2 µm post-manufacturing filtered.Purity: Greater than 90%, as determined by SDS-PAGE.Endotoxin Level: Less than 0.001 ng/µg antibody, as determined by LAL assay.Aggregation: Less than 10%, as determined by HPLC.靶标信息The human CD62L is a 74-95 kDa glycoprotein member of the selectin family of adhesion receptors. L-Selectin is comprised of an aminoterminal C-type lectin binding domain, an epidermal growth factor-like domain, two short consensus repeat (SCR) sequences homologous to those found in complement binding proteins, a short spacer region, a transmembrane region and a short cytoplasmic region. Human CD62L (L-Selectin) is constitutively expressed on all classes of leukocytes including lymphocytes (except a substantial population of memory T cells), monocytes and polymorphonuclear cells.仅用于科研。不用于诊断过程。

数据

CD62L (L-Selectin) Antibody (16-0629-85) in FlowStaining of normal human peripheral blood cells with Anti-Human CD62L (L-Selectin) FITC (left) or APC (right).Appropriate isotype controls were used (open histogram).Cells in the lymphocyte population were used for analysis.

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参考文献：

IF1.Journal of microscopyImage correlation microscopy for uniform illumination."16-0629 was used in Immunohistochemistry to exhibit a novel use for image cross-correlation microscopy."AuthorsGaborski TR,Sealander MN,Ehrenberg M,Waugh RE,McGrath JL2.Biophysical journalMembrane mobility of beta2 integrins and rolling associated adhesion molecules in resting neutrophils."16-0629 was used in Immunofluorescence to present an analytical model to measure the mobility of the four key receptors involved in the neutrophil adhesion cascade."AuthorsGaborski TR,Clark A,Waugh RE,McGrath JL流式3.Nature communicationsHeterogeneity of human bone marrow and blood natural killer cells defined by single-cell transcriptome."Published figure using CD62L (L-Selectin) monoclonal antibody (Product # 16-0629-85) in Flow Cytometry"4.JCI insightBlocking MHC class II on human endothelium mitigates acute rejection."16-0629 was used in Flow cytometry/Cell sorting to establish the immune cell network involved in acute allograft rejection in humans and identify targets for minimising this rejection."AuthorsAbrahimi P,Qin L,Chang WG,Bothwell AL,Tellides G,Saltzman WM,Pober JSICC5.Biophysical journalMembrane mobility of beta2 integrins and rolling associated adhesion molecules in resting neutrophils."16-0629 was used in Immunofluorescence to present an analytical model to measure the mobility of the four key receptors involved in the neutrophil adhesion cascade."AuthorsGaborski TR,Clark A,Waugh RE,McGrath JL

技术参数

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