CD335 (NKp46) Monoclonal Antibody (9E2), Functional Grade, eBioscience™/CD335 (NKp46) 单克隆 (9E2), 功能抗体, eBioscience™
货号：16-3359-82, 16-3359-85
规格：100 µg,500 µg
价格：2177,4830
产品类型：流式抗体
品牌：eBioscience
抗原：CD335
物种：人
宿主：小鼠
抗体亚型：IgG1, kappa
克隆号：9E2
荧光染料：其它
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类型: | 一抗(功能抗体） | 同型对照： | Mouse IgG1 kappa Isotype Control (P3.6.2.8.1), Functional Grade, eBioscience™ |
浓度： | 1 mg/mL | 用法： | 0.25 µg/test（Flow）；Assay-Dependent（FN） |
产品详细信息Description: This 9E2 monoclonal antibody reacts with human CD335, which is also known as NKp46. Expressed on NK cells, CD335 is a member of the natural cytotoxicity receptor family that also includes NKp30 and NKp44. This type I transmembrane glycoprotein is involved in activating and expanding resting NK cells following interaction with dendritic cells to eliminate tumor and virus-infected (e.g., influenza) cells. CD335 also interacts with pancreatic beta cells during the development of type Idiabetes.The 9E2 antibody has been reported to induce cytotoxicity.Applications Reported: This 9E2 antibody has been reported for use in flow cytometric analysis and to induce cytotoxicity in functional assays.Applications Tested: This 9E2 antibody has been tested by flow cytometric analysis of normal human peripheral blood cells. This can be used at less than or equal to 0.25 µg per test. A test is defined as the amount (µg) of antibody that will stain a cell sample in a final volume of 100 µL. Cell number should be determined empirically but can range from 10^5 to 10^8 cells/test. It is recommended that the antibody be carefully titrated for optimal performance in the assay of interest.Storage and handling: Use in a sterile environment.Filtration: 0.2 µm post-manufacturing filtered.Purity: Greater than 90%, as determined by SDS-PAGE.Endotoxin Level: Less than 0.001 ng/µg antibody, as determined by LAL assay.Aggregation: Less than 10%, as determined by HPLC.靶标信息NKp46 (CD335, NCR1, ) is a cytotoxicity-activating receptor that may contribute to the increased efficiency of activated natural killer (NK) cells to mediate tumor cell lysis. NKp46 consists of two Ig-like domains assembled to leukocyte immunoglobulin-like (LIR) and killer inhibitory receptors (KIR).仅用于科研。不用于诊断过程。
数据 |
| CD335 (NKp46) Antibody (16-3359-82) in FlowNormal human peripheral blood cells cells were stained with CD56 Monoclonal Antibody, APC (Product # 17-0566-42) and 0.125 µg of Mouse IgG1 kappa Isotype Control (Product # 14-4714-82) (left) or 0.125 µg of CD335 Monoclonal Antibody, Functional Grade (right) followed by Anti-IgG1 Monoclonal Antibody, Biotin (Product # 13-4015-82) and Streptavidin, PE (Product #12-4317-87). Cells in the lymphocyte gate were used for analysis. |
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参考文献： |
| FN1.Journal of immunology (Baltimore, Md. : 1950)Involvement of the 4-1BB/4-1BBL pathway in control of monocyte numbers by invariant NKT cells."16-3359 was used in Functional assays to show 4-1BB/L costimulation amplified monocyte-mediated proliferation of iNKT cells, indirectly providing a method for monocytes to control their own numbers during infection."AuthorsCole SL,Benam KH,McMichael AJ,Ho LP |
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