CD336 (NKp44) Monoclonal Antibody (44.189), Functional Grade, eBioscience™/CD336 (NKp44) 单克隆 (44.189), 功能抗体, eBioscience™
货号：16-3369-82,16-3369-85,16-3369-025,16-3369-050
规格：100 µg,500 µg,25 mg,50 mg
价格：2215,4667,72266,120443
产品类型：流式抗体
品牌：eBioscience
抗原：CD336
物种：人/小鼠
宿主：小鼠
抗体亚型：IgG2b, kappa
克隆号：44.189
荧光染料：其它
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类型: | 一抗(功能抗体） | 同型对照： | Mouse IgG2b kappa Isotype Control (eBMG2b), Functional Grade, eBioscience™ |
浓度： | 1 mg/mL | 用法： | 0.25 µg/test（Flow）；Assay-Dependent（FN） |
产品详细信息Description: The monoclonal antibody 44.189 reacts with human CD336, which is also known as NKp44 or NCR2. CD336 is a 44-kDa transmembrane glycoprotein belonging to the natural cytotoxicity receptor (NCR) family and contains an ITIM domain located in the cytoplasmic tail. Expression of CD336 and NK cell activation by the receptor requires association with DAP12, an ITAM-containing transmembrane accessory protein. Once thought to be expressed exclusively on IL-2-activated NK cells and a subset ofgamma delta T lymphocytes, studies have shown expression of CD336 on IL-3-stimulated plasmacytoid dendritic cells, alpha beta T cells in the small intestinal epithelium, and T cells in cord blood. CD336 has been shown to be involved in the innate response of activated NK cells against viral infection and tumor cell proliferation.The 44.189 antibody has been reported to facilitate CD336 crosslinking.Applications Reported: This 44.189 antibody has been reported for use in flow cytometric analysis and functional assays (receptor crosslinking).Applications Tested: This 44.189 antibody has been tested by flow cytometric analysis of normal human peripheral blood cells. This can be used at less than or equal to 0.25 µg per test. A test is defined as the amount (µg) of antibody that will stain a cell sample in a final volume of 100 µL. Cell number should be determined empirically but can range from 10^5 to 10^8 cells/test. It is recommended that the antibody be carefully titrated for optimal performance in the assay of interest.Storage and handling: Use in a sterile environment.Filtration: 0.2 µm post-manufacturing filtered.Purity: Greater than 90%, as determined by SDS-PAGE.Endotoxin Level: Less than 0.001 ng/µg antibody, as determined by LAL assay.Aggregation: Less than 10%, as determined by HPLC.靶标信息CD336 is also known as NKp44 or NCR2. CD336 is a 44-kDa transmembrane glycoprotein belonging to the natural cytotoxicity receptor (NCR) family and contains an ITIM domain located in the cytoplasmic tail. Expression of CD336 and NK cell activation by the receptor requires association with DAP12, an ITAM-containing transmembrane accessory protein. Once thought to be expressed exclusively on IL-2-activated NK cells and a subset of gamma delta T lymphocytes, studies have shown expression of CD336 onIL-3-stimulated plasmacytoid dendritic cells, alpha beta T cells in the small intestinal epithelium, and T cells in cord blood. CD336 has been shown to be involved in the innate response of activated NK cells against viral infection and tumor cell proliferation.仅用于科研。不用于诊断过程。生物信息学蛋白别名:CD336; CD336 antigen; lymphocyte antigen 95 (activating NK-receptor; NK-p44); Lymphocyte antigen 95 homolog; lymphocyte antigen 95 homolog (activating NK-receptor; NK-p44); Natural cytotoxicity triggering receptor 2; Natural killer cell p44-related protein; natural killer cell receptor; NK cell activating receptor (NKp44); NK cell-activating receptor; NK-p44; NK-p44dJ149M18.1基因别名:CD336; dJ149M18.1; LY95; NCR2; NK-p44; NKP44UniProt ID:(Human) O95944Entrez Gene ID:(Human) 9436
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