CD31 (PECAM-1) Monoclonal Antibody (WM-59 (WM59)), Functional Grade, eBioscience™/CD31 (PECAM-1) 单克隆 (WM-59 (WM59)), 功能抗体, eBioscience™

货号：16-0319-82,16-0319-38,16-0319-025,16-0319-050

规格：100 µg,5 mg,25 mg,50 mg

价格：2564,24089,72266,120443

产品类型：流式抗体

品牌：eBioscience

抗原：CD31

物种：人

宿主：小鼠

抗体亚型：IgG1, kappa

克隆号：WM-59 (WM59)

荧光染料：其它

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类型:	一抗(功能抗体）	同型对照：	Mouse IgG1 kappa Isotype Control (P3.6.2.8.1), Functional Grade, eBioscience™
浓度：	1 mg/mL	用法：	0.25 µg/test（Flow）;Assay-Dependent（对照）;Assay-Dependent（功能检测）

产品详细信息Description: The WM59 monoclonal antibody reacts with human CD31, also known as platelet-endothelial cell adhesion molecule-1 (PECAM-1) and gpIIa. This 130-140 kDa surface protein is expressed by endothelial cells and at low levels on leukocytes and platelets. It has been reported that CD38 binds to CD31. Homotypic interaction of CD31 is important in adhesion, cell-cell and cell-matrix interaction, and signal transduction.Applications Reported: The WM-59 (WM59) antibody has been reported for use in flow cytometric analysis.Applications Tested: The WM-59 (WM59) antibody has been tested by flow cytometric analysis of normal human peripheral blood cells. This can be used at less than or equal to 0.25 µg per test. A test is defined as the amount (µg) of antibody that will stain a cell sample in a final volume of 100 µL. Cell number should be determined empirically but can range from 10^5 to 10^8 cells/test. It is recommended that the antibody be carefully titrated for optimal performance in the assay of interest.Storage and handling: Use in a sterile environment.Filtration: 0.2 µm post-manufacturing filtered.Purity: Greater than 90%, as determined by SDS-PAGE.Endotoxin Level: Less than 0.001 ng/µg antibody, as determined by LAL assay.Aggregation: Less than 10%, as determined by HPLC.靶标信息CD31 (platelet endothelial cell adhesion molecule-1, PECAM-1) is an inhibitory coreceptor involved in regulation of T cell and B cell signaling by a dual immunoreceptor tyrosine-based inhibitory motif (ITIM) that upon associated kinases-mediated phosphorylation provide docking sites for protein-tyrosine phosphatases. CD31 is expressed ubiquitously within the vascular compartment and is located mainly at junctions between adjacent cells. N-terminal Ig-like domain of CD31 is responsible for its homophilic binding, which plays an important role in cell-cell interactions. CD31 is a multifunctional molecule with diverse roles in modulation of integrin-mediated cell adhesion, transendothelial migration, angiogenesis, apoptosis, negative regulation of immunoreceptor signaling, autoimmunity, macrophage phagocytosis, IgE-mediated anaphylaxis and thrombosis. It is one of key regulatory molecules in vascular system.仅用于科研。不用于诊断过程。

数据

CD31 (PECAM-1) Antibody (16-0319-82) in FlowStaining of normal human peripheral blood cells with Anti-Human CD31 (PECAM-1) FITC (left) or PE (right).Appropriate isotype controls were used (open histogram).Cells in the monocyte population were used for analysis.

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参考文献：

流式1.Stem cell reportsProstaglandin E2Is Required for BMP4-Induced Mesoderm Differentiation ofHuman Embryonic Stem Cells."Published figure using CD31 (PECAM-1) monoclonal antibody (Product # 16-0319-82) in Flow Cytometry"2.The Journal of investigative dermatologySpatial and Single-Cell Transcriptional Profiling Identifies Functionally Distinct Human Dermal Fibroblast Subpopulations."Published figure using CD31 (PECAM-1) monoclonal antibody (Product # 16-0319-82) in Flow Cytometry"3.OncoimmunologyIncreased infiltration and tolerised antigen-specific CD8+TEMcells in tumor but not peripheral blood have no impact on survival of HCMV+glioblastoma patients."Published figure using CD31 (PECAM-1) monoclonal antibody (Product # 16-0319-82) in Flow Cytometry"IHC4.BiomaterialsMesenchymal stromal cells form vascular tubes when placed in fibrin sealant and accelerate wound healing invivo."Published figure using CD31 (PECAM-1) monoclonal antibody (Product # 16-0319-82) in Immunofluorescence"IF5.Journal of translational medicineEndothelial and smooth muscle cells derived from human cardiac explants demonstrate angiogenic potential and suitable for design of cell-containing vascular grafts."Published figure using CD31 (PECAM-1) monoclonal antibody (Product # 16-0319-82) in Immunofluorescence"6.OncotargetAcidic pH reduces VEGF-mediated endothelial cell responses by downregulation of VEGFR-2; relevance for anti-angiogenic therapies."Published figure using CD31 (PECAM-1) monoclonal antibody (Product # 16-0319-82) in Immunofluorescence"

技术参数

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