CD61 (Integrin beta 3) Monoclonal Antibody (2C9.G3), Functional Grade, eBioscience™/CD61 (Integrin beta 3) 单克隆 (2C9.G3),功能抗体, eBioscience™

货号：16-0611-82,16-0611-38,16-0611-025,16-0611-050

规格：100 µg,5 mg,25 mg,50 mg

价格：1865,24089,72266,120443

产品类型：流式抗体

品牌：eBioscience

抗原：CD61

物种：人/小鼠/大鼠

宿主：Armenian hamster仓鼠

抗体亚型：IgG

克隆号：2C9.G3

荧光染料：其它

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类型:	一抗(功能抗体）	同型对照：	Armenian Hamster IgG Isotype Control (eBio299Arm), Functional Grade, eBioscience™
浓度：	1 mg/mL	用法：	0.5 µg/test（Flow）;Assay-Dependent（中和）;Assay-Dependent（功能检测）

产品详细信息Description: The 2C9.G3 (HMb3-1) monoclonal antibody reacts with mouse and rat CD61, also known as the integrin beta3. CD61 is expressed by activated T cells, granulocytes, and platelet. CD61 associates non-covalently with two integrin alpha subunits; alphaV (CD51) to form Vitronectin Receptor and alphaIib (CD41) to form gpIIb/IIIa. These heterodimeric complexes are responsible for adhesion to extracellular matrix components including fibrinogen, fibronectin, fibronectin, vitronectin, thrombospondin and von Willebrand factor.Applications Reported: The 2C9.G3 antibody has been reported for use in flow cytometric analysis. 2C9.G3 has also been reported in blocking of ligand binding and some adhesive processes.Applications Tested: The 2C9.G3 antibody has been tested by flow cytometric analysis of mouse splenocytes and bone marrow cells. This can be used at less than or equal to 0.5 µg per test. A test is defined as the amount (µg) of antibody that will stain a cell sample in a final volume of 100 µL. Cell number should be determined empirically but can range from 10^5 to 10^8 cells/test. It is recommended that the antibody be carefully titrated for optimal performance in the assay of interest.Storage and handling: Use in a sterile environment.Filtration: 0.2 µm post-manufacturing filtered.Purity: Greater than 90%, as determined by SDS-PAGE.Endotoxin Level: Less than 0.001 ng/µg antibody, as determined by LAL assay.Aggregation: Less than 10%, as determined by HPLC.靶标信息CD61 (GPIIIa, ITGB3) is a glycoprotein found on megakaryocytes, platelets and their precursors. CD61 antigen plays a role in platelet aggregation and also as a receptor for fibrinogen, fibronectin, von Willebrand factor and vitronectrin. CD61 is a 105 kDa glycoprotein that associates with either the alpha 11b integrin (CD41) or the alpha V integrin (CD51) at the cell surface. CD61 is expressed on platelets and megakaryocytes in association with CD41, and on endothelial cells, monocytes, platelets and osteoclasts in association with CD51. CD61 is a receptor for fibrinogen, fibronectin, Von Willebrand Factor, vitronectin and thrombospondin. The CD61 protein product is composed of an alpha chain and a beta chain. A given chain may combine with multiple partners resulting in different integrins. CD61 is found along with the alpha IIb chain in platelets. Like other integrins, CD61 is known to participate in cell adhesion as well as cell-surface mediated signaling. Diseases associated with CD61 dysfunction include Glanzmann Thrombasthenia and Platelet type-16 Bleeding Disorder.仅用于科研。不用于诊断过程。

数据

CD61 (Integrin beta 3) Antibody (16-0611-82) in FlowStaining of mouse bone marrow with Anti-Mouse/Rat CD61 (Integrin beta 3) FITC (left) or PE (right). Appropriate isotype controls were used (open histogram). Cells in the myeloid population were used for analysis.

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参考文献：

流式1.Cancer cellHoxa9 and Meis1 Cooperatively Induce Addiction to Syk Signaling by Suppressing miR-146a in Acute Myeloid Leukemia."Published figure using CD61 (Integrin beta 3) monoclonal antibody (Product # 16-0611-82) in Flow Cytometry"2.eLifeThe fibronectin synergy site re-enforces cell adhesion and mediates a crosstalk between integrin classes."Published figure using CD61 (Integrin beta 3) monoclonal antibody (Product # 16-0611-82) in Flow Cytometry"3.The Journal of investigative dermatologyβ1 integrins with individually disrupted cytoplasmic NPxY motifs are embryonic lethal but partially active in the epidermis."Published figure using CD61 (Integrin beta 3) monoclonal antibody (Product # 16-0611-82) in Flow Cytometry"功能检测4.The Journal of biological chemistryPlasminogen activator inhibitor-1 regulates integrin alphavbeta3 expression and autocrine transforming growth factor beta signaling.IF5.eLifeThe fibronectin synergy site re-enforces cell adhesion and mediates a crosstalk between integrin classes."Published figure using CD61 (Integrin beta 3) monoclonal antibody (Product # 16-0611-82) in Flow Cytometry"中和6.Scientific reportsWISP1-αvβ3 integrin signaling positively regulates TLR-triggered inflammation response in sepsis induced lung injury.

技术参数

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