CD62P (P-Selectin) Monoclonal Antibody (Psel.KO2.12), Functional Grade, eBioscience™/CD62P (P-Selectin) 单克隆 (Psel.KO2.12), 功能抗体, eBioscience™
货号：16-0622-81,16-0622-85,16-0622-025,16-0622-050
规格：50 µg,500 µg,25 mg,50 mg
价格：1394,3735,72266,120443
产品类型：流式抗体
品牌：eBioscience
抗原：CD62P
物种：小鼠
宿主：小鼠
抗体亚型：IgG1, kappa
克隆号：Psel.KO2.12
荧光染料：其它
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类型: | 一抗(功能抗体） | 同型对照： | Mouse IgG1 kappa Isotype Control (P3.6.2.8.1), Functional Grade, eBioscience™ |
浓度： | 1 mg/mL | 用法： | 0.25 µg/test（Flow）;Assay-Dependent（中和）;Assay-Dependent（功能检测） |
产品详细信息Description: CD62P (also known as P-selectin and GMP-140) is a 140-kDa cell adhesion molecule that can be induced on endothelial cells and platelets. During inflammation, this selectin mediates adhesion of monocytes and neutrophils to activated platelets, as well as leukocyte rolling on endothelial cells. The major ligand for CD62P on neutrophils is P-selectin glycoprotein ligand-1 (PSGL-1). This monoclonal antibody recognizes an epitope that is conserved across several species (e.g. mouse, human, and rat).Applications Reported: This Psel.KO2.12 antibody has been reported for use in flow cytometric analysis and for blocking CD62P-mediated adhesion.Applications Tested: This Psel.KO2.12 antibody has been tested by flow cytometric analysis on thrombin-activated mouse platelets. This can be used at less than or equal to 0.25 µg per test. A test is defined as the amount (µg) of antibody that will stain a cell sample in a final volume of 100 µL. Cell number should be determined empirically but can range from 10^5 to 10^8 cells/test. It is recommended that the antibody be carefully titrated for optimal performance in the assay of interest.Storage and handling: Use in a sterile environment.Filtration: 0.2 µm post-manufacturing filtered.Purity: Greater than 90%, as determined by SDS-PAGE.Endotoxin Level: Less than 0.001 ng/µg antibody, as determined by LAL assay.Aggregation: Less than 10%, as determined by HPLC.靶标信息P-selectin (Selectin P, GMP-140, LECAM3, CD62 antigen-like family member) is a 140 kDa type 1 transmembrane glycoprotein, and is one of the most commonly studied proteins that regulate cell rolling. P-selectin is stored in the Weibel-Palade bodies of endothelial cells, as well as in a-granules of platelets. From there, it can be rapidly brought to the cell surface after exposure to thrombin, histamine, complement 5a, Ca21 ionophores, or adenosine diphosphate. P-selectin protein redistributes tothe plasma membrane during platelet activation and degranulation and mediates the interaction of activated endothelial cells or platelets with leukocytes. P-selectin plays an important role in adhesive processes between leucocytes and endothelial cells, and is a calcium dependent receptor that binds to sialylated forms of Lewis blood group carbohydrate antigens found on neutrophils and monocytes. P-selectin is constitutively expressed in inflammation and contributes to atherogenesis, thrombosis and tissue destruction. Clinically, P-selectin is used to distinguish heparin induced thrombocytopenia with and without thrombosis.仅用于科研。不用于诊断过程。
数据 |
| CD62P (P-Selectin) Antibody (16-0622-81) in FlowStaining of thrombin-activated mouse platelets with 0.125 µg Mouse IgG1, K Isotype Control Functional Grade Purified (Product # 16-4714-82) (left) or Anti-Mouse CD62P (P-Selectin) Functional Grade Purified followed by Anti-Mouse IgG1 PE (right) and Anti-Mouse CD41 FITC (Product # 11-0411-82). |
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参考文献： |
| 功能检测1.Journal of ultrasound in medicine : official journal of the American Institute of Ultrasound in MedicineMolecular ultrasound imaging using a targeted contrast agent for assessing early tumor response to antiangiogenic therapy."16-0622 was used in in vivo experiments to explore a novel method for angiogenesis evaluation and disease staging in cancer."AuthorsSorace AG,Saini R,Mahoney M,Hoyt K |
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