CD102 (ICAM-2) Monoclonal Antibody (3C4 (mIC2/4)), Functional Grade, eBioscience™/CD102 (ICAM-2)单克隆 (3C4 (mIC2/4)), 功能抗体, eBioscience™

货号：16-1021-82,16-1021-85,16-1021-38,16-1021-025,16-1021-050

规格：100 µg,500 µg,5 mg,25 mg,50 mg

价格：1299,3282,24089,72266,120443

产品类型：流式抗体

品牌：eBioscience

抗原：CD102

物种：小鼠

宿主：大鼠

抗体亚型：IgG2a, kappa

克隆号：3C4 (mIC2/4)

荧光染料：其它

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类型:	一抗(功能抗体）	同型对照：	Rat IgG2a kappa Isotype Control (eBR2a), Functional Grade, eBioscience™
浓度：	1 mg/mL	用法：	0.25 µg/test（Flow）;Assay-Dependent（功能检测）

产品详细信息Description: The monoclonal antibody 3C4 (mIC2/4) recognizes mouse CD102, also known as intercellular adhesion molecule-2 (ICAM-2). CD102, a member of the Immunoglobulin superfamily of receptors with 2 extracellular Ig domains, binds LFA (CD11a/CD18) and Mac-1 (CD11b/CD18), thereby mediating cellular interactions to lymphocytes. CD102 plays a role in NK cytotoxicity and migration, and lymphocyte recirculation. Expression of CD102 is found on most lymphocytes, monocytes and platelets.The3C4 (mIC2/4) antibody blocks interaction of lymphocytes with antigen presenting cells.Applications Reported: This 3C4 (mIC2/4) antibody has been reported for use in flow cytometric analysis and functional assays.Applications Tested: This 3C4 (mIC2/4) antibody has been tested by flow cytometric analysis of mouse splenocytes. This can be used at less than or equal to 0.25 µg per test. A test is defined as the amount (µg) of antibody that will stain a cell sample in a final volume of 100 µL. Cell number should be determined empirically but can range from 10^5 to 10^8 cells/test. It is recommended that the antibody be carefully titrated for optimal performance in the assay of interest.Storage and handling: Use in a sterile environment.Filtration: 0.2 µm post-manufacturing filtered.Purity: Greater than 90%, as determined by SDS-PAGE.Endotoxin Level: Less than 0.001 ng/µg antibody, as determined by LAL assay.Aggregation: Less than 10%, as determined by HPLC.靶标信息ICAM-2 is a member of the intercellular adhesion molecule (ICAM) family. All ICAM proteins are type I transmembrane glycoproteins, contain 2-9 immunoglobulin-like C2-type domains, and bind to the leukocyte adhesion LFA-1 protein. ICAM-2 may play a role in lymphocyte recirculation by blocking LFA-1-dependent cell adhesion. It mediates adhesive interactions important for antigen-specific immune response, NK-cell mediated clearance, lymphocyte recirculation, and other cellular interactions important for immune response and surveillance. Several transcript variants encoding the same protein have been found for this gene. Diseases associated with ICAM2 include Colon Carcinoma In Situ.仅用于科研。不用于诊断过程。

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参考文献：

功能检测1.Kidney internationalParathyroid hormone-related protein protects renal tubuloepithelial cells from apoptosis by activating transcription factor Runx2."16-1021 was used in Functional assays to study the mechanism by which parathyroid hormone-related protein protects renal tubuloepithelial cells from apoptosis."AuthorsArdura JA,Sanz AB,Ortiz A,Esbrit P

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