Cardiac Troponin T Monoclonal Antibody (7G7)
货号：MA1-24621
规格：200μg
价格：4880
产品类型：抗体和染料
品牌：Thermo Fisher
物种：人
宿主：小鼠
抗体亚型：IgG1, kappa
荧光染料：其它
| 抗体类型 | 单抗 | 同型对照： | |
| 浓度： | 5.3 mg/mL | 用法： | 1:500(WB)；Assay Dependent(ELISA)；Assay Dependent(AP) |
| 产品详细信息MA1-24621 will not react with mouse, rat, feline, canine, fish, goat, porcine, or rabbit.靶标信息Cardiac Troponin T is the tropomyosin-binding subunit of the troponin complex, which is located on the thin filament of striated muscles and regulates muscle contraction in response to alterations in intracellular calcium ion concentration. Cardiac Troponin T is important in proper muscle function and myofibril formation. In the human heart, four cTnT isoforms are expressed in a developmentally regulated manner. Cardiac Troponin T expression in the human heart is affected by heart failure. Mutations within the Cardiac Troponin T protein have been associated with familial hypertrophic cardiomyopathy as well as with dilated cardiomyopathy. Transcripts for the Cardiac Troponin T gene undergo alternative splicing that results in many tissue-specific isoforms |
| 数据 |
| Cardiac Troponin T Antibody (MA1-24621) in WBWestern blot analysis was performed on whole cell extracts (30 µg lysate) of iPSC (Lane 1), iPSC differentiated to Cardiomyocytes (Lane 2), tissue extracts (30 µg lysate) of Mouse Heart (Lane 3), Rat Heart (Lane 4), Mouse Skeletal Muscle (Lane 5) and Rat Skeletal Muscle (Lane 6). The blot was probed with Anti-Cardiac Troponin T Monoclonal Antibody (7G7) (Product # MA1-24621, 1:500 dilution) and detected by chemiluminescence using Goat anti-Mouse IgG (H+L) Superclonal™ Secondary Antibody, HRP conjugate (Product # A28177, 0.25 µg/ml, 1:4000 dilution). A 40 kDa band corresponding to Cardiac Troponin T was detected in Cardiomyocytes, Mouse Heart and Rat Heart and not in Mouse and Rat Skeletal Muscle which are reported negative for Cardiac Troponin T expression. |
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