CD25 Monoclonal Antibody (B-B10), eBioscience™

货号：BMS134

规格：100 µg

价格：1924

产品类型：流式抗体

品牌：eBioscience

抗原：CD25

物种：人

宿主：小鼠

抗体亚型：IgG1, kappa

克隆号：B-B10

荧光染料：其它

类型:	一抗	同型对照：	IgG1
浓度：	1 mg/mL	用法：	Assay-Dependent（Flow）

产品详细信息Description: Anti-IL-2R recognizes the expressed product of the IL2RA gene. BMS134 (BB10) inhibits IL -2 dependent human T-cell proliferation. This antibody is validated for use in Flow Cytometry, WB and Functional studies as neutralizing antibody.Applications Tested: Flow Cytometry, Functional Studies (Blocking).Purity: >95%.靶标信息CD25 (IL2 receptor alpha chain/IL2RA) is a cytokine that plays a role in the proliferation of T and B lymphocytes. The receptor of this cytokine (IL2RA) is a heterotrimeric protein complex with a gamma chain also shared by interleukin 4 (IL4) and interleukin 7 (IL7). IL2RA, IL2R beta chain (IL2RB), and the IL2R gamma chain (IL2RG), constitute the high-affinity IL2 receptor. Homodimeric IL2RA chains result in low-affinity receptor, while homodimeric IL2RB chains produce a medium-affinity receptor. The expression of IL2 in mature thymocytes is monoallelic, which represents an unusual regulatory mode for controlling the precise expression of a single gene. IL2 is primarily produced by mature T cells. IL2 plays an important role as a growth factor, differentiation factor, and regulator of cell death. IL-2 stimulates the proliferation of B cells, augments natural killer cell activity, and inhibits granulocyte macrophage colony formation. The targeted disruption of a similar gene in mice leads to ulcerative colitis-like disease, which suggests a role in the immune response to antigenic stimuli. Mutations in this gene are associated with interleukin 2 receptor alpha deficiency.仅用于科研。不用于诊断过程。

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文献

1.Revista da Sociedade Brasileira de Medicina TropicalGlucocorticoid-induced tumor necrosis factor receptor expression in patients with cervical human papillomavirus infection."BMS134 was used in Immunohistochemistry to support GITR as a potential target for immune therapy of cervical cancer and as a disease evolution biomarker."AuthorsPadovani CT,Bonin CM,Tozetti IA,Ferreira AM,Fernandes CE,Costa IP2.Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow TransplantationPreactivation with IL-12, IL-15, and IL-18 induces CD25 and a functional high-affinity IL-2 receptor on human cytokine-induced memory-like natural killer cells."BMS134 was used in Functional assays to demonstrate that human cytokine-induced memory-like NK cells respond to IL-2 via IL-2Rαβγ with enhanced survival and functionality."AuthorsLeong JW,Chase JM,Romee R,Schneider SE,Sullivan RP,Cooper MA,Fehniger TA

技术参数

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