CD137 Ligand (4-1BB Ligand) Monoclonal Antibody (4H3), APC
货号：17-5906-42
规格：100 Tests
价格：2915
产品类型：流式抗体
品牌：Thermo Fisher
物种：人
宿主：小鼠
抗体亚型：IgG1, kappa
荧光染料：APC
| 抗体类型 | 单抗 | 同型对照： | Mouse IgG1 kappa Isotype Control (P3.6.2.8.1), APC |
| 浓度： | 5 µL/Test | 用法： | 5 μL (0.25 μg)/test (Flow) |
| 产品详细信息This 4H3 monoclonal antibody recognizes human CD137 ligand, also known as 4-1BB ligand, TNFSF9, or CDw137L.Applications Reported: This 4H3 antibody has been reported for use in flow cytometric analysis.Applications Tested: This 4H3 antibody has been pre-diluted and tested by flow cytometric analysis of stimulated normal human peripheral blood cells. This may be used at 5 µL (0.25 µg) per test. A test is defined as the amount (µg) of antibody that will stain a cell sample in a final volume of 100 µL. Cell number should be determined empirically but can range from 10^5 to 10^8 cells/test.Excitation: 633-647 nm; Emission: 660 nm; Laser: Red Laser.Filtration: 0.2 µm post-manufacturing filtered.靶标信息CD137 ligand (CD137L) is a type II membrane protein and part of the TNF superfamily. CD137L is a co-stimulatory molecule that is expressed on antigen presenting cells (DCs, monocytes/macrophages, B cells) and is upregulated upon activation. Its receptor, CD137/4-1BB, is found on a variety of cells, including inflamed endothelial cells, where its expression enhances extravasation of CD137L expressing monocytes. Activated T cells also express CD137, and engagement with CD137L enhances T cell proliferation, IL-2 secretion, survival, and cytotoxic activity. CD137L is also expressed on a majority of B-cell lymphomas, including mantle cell lymphoma, follicular lymphoma, and diffuse large B-cell lymphoma (but it is lacking on Hodgkin lymphoma and T-cell lymphoma). CD137L is also expressed in carcinoma cell lines, and is thought to be involved in T cell-tumor cell interactions. |
| 数据 |
| CD137 Ligand (4-1BB Ligand) Antibody (17-5906-41) in FlowNormal human peripheral blood cells were unstimulated (left) or stimulated with 10 µg/mL of F (ab’)2 Anti-Human IgM+IgG Functional Grade Purified (Product # 16-5099-85) and 3 µg/mL CD40 Functional Grade Monoclonal Antibody (Product # 16-0409-81) (right) for 4 hours. Cells were surface stained with Anti-Human CD19 PE-Cyanine7 (Product # 25-0199-42), Anti-Human CD69 eFluor® 450 (Product # 48-0699-42), and Anti-Human CD137 Ligand (4-1BB Ligand) APC. CD19 positive cells in the lymphocyte gate were used for analysis. |
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