CD272 (BTLA) Monoclonal Antibody (MIH26), Biotin
货号：13-5979-80
规格：25 µg
价格：1132
产品类型：流式抗体
品牌：Thermo Fisher
物种：人
宿主：小鼠
抗体亚型：IgG2a, kappa
荧光染料：Biotin
| 抗体类型 | 单抗 | 同型对照： | Mouse IgG2a kappa Isotype Control (eBM2a), Biotin |
| 浓度： | 0.5 mg/mL | 用法： | 0.125μg/test (Flow)； |
| 产品详细信息Description: The BTLA monoclonal antibody reacts with human B and T lymphocyte attenuator (BTLA). BTLA is expressed by peripheral lymphocytes, splenic macrophages, developing B cells in the bone marrow and developing T cells in the thymus and mature, but not immature bone marrow-derived dendritic cells. BTLA is implicated as a negative regulator of the activation and/or function of various hemopoietic cell types. It is reported that BTLA binds to B7-H4, but further studies are needed to confirmthis interaction.Applications Reported: This MIH26 antibody has been reported for use in flow cytometric analysis.Applications Tested: This MIH26 antibody has been tested by flow cytometric analysis of normal human peripheral blood cells. This can be used at less than or equal to 0.125 µg per test. A test is defined as the amount (µg) of antibody that will stain a cell sample in a final volume of 100 µL. Cell number should be determined empirically but can range from 10^5 to 10^8 cells/test. It is recommended that the antibody be carefully titrated for optimal performance in the assay of interest.Filtration: 0.2 µm post-manufacturing filtered.靶标信息BTLA or B and T-lymphocyte attenuator is a member of the co-inhibitory receptors of the CD28 superfamily. BTLA is a lymphocyte inhibitory receptor which inhibits lymphocytes during immunes responses. BTLA is constitutively expressed on most CD4+ and CD8+ T cells and its expression progressively decreases upon T cell activation. It remains expressed on Th1 cells, but not Th2 cells. BTLA is a unique co-receptor that interacts with the tumor necrosis factor receptor superfamily member herpesvirus entry mediator (HVEM). This interation is an important pathway regulating lymphocyte activation and/or homeostasis in the immune response. |
| 数据 |
| CD272 (BTLA) Antibody (13-5979-80) in FlowStaining of normal human peripheral blood cells with Anti-Human CD3 APC (Product # 17-0038-42) and 0.125 µg of Biotin Mouse IgG2a, K Iso Cntrl (Product # 13-4724-85) (left) or 0.06 µg of Anti-Human CD272 (BTLA) Biotin (right) followed by Streptavidin PE (Product # 12-4317-87). Cells in the lymphocyte gate were used for analysis. |
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| 参考文献： |
| 1.Cancer immunology researchProgression of Lung Cancer Is Associated with Increased Dysfunction of T Cells Defined by Coexpression of Multiple Inhibitory Receptors."13-5979 was used in Flow cytometry/Cell sorting to characterise the diversity and expression patterns of inhibitory receptors on tumour-infiltrating T cells from patients with non-small cell lung cancer."AuthorsThommen DS,Schreiner J,Müller P,Herzig P,Roller A,Belousov A,Umana P,Pisa P,Klein C,Bacac M,Fischer OS,Moersig W,Savic Prince S,Levitsky V,Karanikas V,Lardinois D,Zippelius A |
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