Mouse anti Human TIMP-2, clone D08-1D4
货号：MCA5969GA
规格：0.1 mg
价格：2576
产品类型：免疫组化一抗
品牌：Bio-Rad
抗原：TIMP-2
物种：人
宿主：小鼠
抗体亚型：IgG1
克隆号：D08-1D4
荧光染料：Purified
| 产品介绍 | | |
| Mouse anti Human TIMP-2, clone D08-1D4,recognizes the human tissue matrix metalloprotease inhibitor (TIMP)-2, a 220 amino acid ~22kDa member of the TIMP family.TIMP-2 is a inhibitor of matrix metalloproteases but can also interact with MT1-MMP to enable the cell-surface activation of pro-MMP-2 (Lambertet al.2004andBakeret al.2002). TIMP-2 selectively inhibits the growth of endothelial cells through an MMP-independent mechanism (Murphyet al.1993andMoseset al.1990). |
| 产品详情 | | |
| Target Species | Human |
| Product Form | Purified IgG - liquid |
| Preparation | Purified IgG prepared by affinity chromatography on Protein G from ascites |
| Buffer Solution | Phosphate buffered saline |
| Immunogen | E. coliderived recombinant protein corresponding to aa 27-220 of human TIMP-2 |
| Fusion Partners | Spleen cells from immunised BALB/c mice were fused with cells of the mouse SP2/0 myeloma cell line. |
| Preservative Stabilisers | <0.1% Sodium Azide (NaN3) |
| Approx. Protein Concentrations | IgG concentration 1.0 mg/ml |
| Regulatory | For research purposes only |
| Guarantee | 12 months from date of despatch |
| 存储条件 | | |
| This product is shipped at ambient temperature. It is recommended to aliquot and store at -20°C on receipt. When thawed, aliquot the sample as needed. Keep aliquots at 2-8°C for short term use (up to 4 weeks) and store the remaining aliquots at -20°C.Avoid repeated freezing and thawing as this may denature the antibody. Storage in frost-free freezers is not recommended. |
| 应用 | | |
| Application Name | Verified | Min Dilution | Max Dilution |
| ELISA | √ | | |
| This product has been reported to work in the following applications. This information is derived from testing within our laboratories, peer-reviewed publications or personal communications from the originators. Please refer to references indicated for further information. For general protocol recommendations, please visit theantibody protocolspage.Where this antibody has not been tested for use in a particular technique this does not necessarily exclude its use in such procedures. Suggested working dilutions are given as a guide only. It is recommended that the user titrates the antibody for use in their own system using appropriate negative/positive controls. |
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| 文献 |
| 1.Baker, A.H.et al.(1998) Divergent effects of tissue inhibitor of metalloproteinase-1, -2, or -3 overexpression on rat vascular smooth muscle cell invasion, proliferation, and death in vitro. TIMP-3 promotes apoptosis.J Clin Invest. 101 (6): 1478-87.2.Moses, M.A.et al.(1990) Identification of an inhibitor of neovascularization from cartilage.Science. 248 (4961): 1408-10.3.Murphy, A.N.et al.(1993) Tissue inhibitor of metalloproteinases-2 inhibits bFGF-induced human microvascular endothelial cell proliferation.J Cell Physiol. 157 (2): 351-8.4.Lambert, E.et al.(2004) TIMPs as multifacial proteins.Crit Rev Oncol Hematol. 49 (3): 187-98. |
技术参数 产品应用 Elisa
产品类型 Monoclonal Antibody
推荐用于 Elisa
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