mouse anti PROSTATE SPECIFIC MEMBRANE antigen
货号：MCA2885
规格：0.1 mg
价格：2550
产品类型：免疫组化一抗
品牌：Bio-Rad
抗原：Prostate Specific Membrane Antigen
物种：人
宿主：小鼠
抗体亚型：IgG1
克隆号：GCP-04
荧光染料：Purified
| 产品介绍 | | |
| Mouse anti prostate specific Membrane Antigen antibody, clone GCP-04recognises amino acids 100-104 of the extracellular domain of prostate specific membrane antigen (PSMA), otherwise known as GCPII (glutamate carboxypeptidase II), a 95-110 kDa type II transmembrane glycoprotein and member of the peptidase M28 family.Nomenclature for GCPII is dependent upon tissue specificity. PSMA is assigned to GCPII of prostate origin which is up-regulated in prostate cancer and a reliable diagnostic marker. Folate hydrolase (FOLH1) describes GCPII in the intestine and is required for folate uptake, whilst NAALADase refers to GCPII expressed in the central nervous system, which acts to cleave N-acetylaspartylglutamate (NAAG) to release glutamate, implicated in pathological conditions including Alzheimer’s and Huntington’s disease. |
| 产品详情 | | |
| Target Species | Human |
| Product Form | Purified IgG - liquid |
| Preparation | Purified IgG prepared by affinity chromatography on Protein A |
| Buffer Solution | Phosphate buffered saline |
| Immunogen | Recombinant fragment corresponding to amino acids 44-750 of human GCPII. |
| Preservative Stabilisers | <0.1% Sodium Azide (NaN3) |
| Approx. Protein Concentrations | IgG concentration 1 mg/ml |
| Regulatory | For research purposes only |
| Guarantee | 12 months from date of despatch |
| 存储条件 | | |
| This product is shipped at ambient temperature. It is recommended to aliquot and store at -20°C on receipt. When thawed, aliquot the sample as needed. Keep aliquots at 2-8°C for short term use (up to 4 weeks) and store the remaining aliquots at -20°C.Avoid repeated freezing and thawing as this may denature the antibody. Storage in frost-free freezers is not recommended. |
| 应用 | | |
| Application Name | Verified | Min Dilution | Max Dilution |
| Western Blotting | √ | 0.5 | 1.0ug/ml |
| This product has been reported to work in the following applications. This information is derived from testing within our laboratories, peer-reviewed publications or personal communications from the originators. Please refer to references indicated for further information. For general protocol recommendations, please visit theantibody protocolspage.Where this antibody has not been tested for use in a particular technique this does not necessarily exclude its use in such procedures. Suggested working dilutions are given as a guide only. It is recommended that the user titrates the antibody for use in their own system using appropriate negative/positive controls. |
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| Goat anti Rat IgG:Alk. Phos. (Mouse Adsorbed) | STAR117A | WB；E | 0.5mg |
| 文献 |
| 1.Rovenská, M.et al.(2008) Tissue expression and enzymologic characterization of human prostate specific membrane antigen and its rat and pig orthologs.Prostate. 68 (2): 171-82.2.Barinka, C.et al.(2004) Identification of the N-glycosylation sites on glutamate carboxypeptidase II necessary for proteolytic activity.Protein Sci. 13 (6): 1627-35. |
技术参数 产品应用 IHC(P);WB
产品类型 单克隆抗体
推荐用于 IHC(P);WB
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