Mouse anti Rat CD11b, clone OX-42
货号：MCA275EL
规格：0.5 mg
价格：5143
产品类型：流式抗体
品牌：Bio-Rad
抗原：CD11b
物种：大鼠
宿主：小鼠
抗体亚型：IgG2a
克隆号：OX-42
荧光染料：Low Endotoxin
| 产品介绍 | | |
| Mouse anti Rat CD11b, clone OX-42recognizes rat CD11b, also known asintegrin alpha-M, the receptor for the iC3b component of complement. CD11b is a 1151 amino acid single pass type 1 transmembrane glycoprotein posessing a singlevWFAdomain and multipleFG-GAPrepeats. CD11b is expressed on most macrophages, including resident and activated peritoneal macrophages and Kupffer cells and around 35% of alveolar macrophages. The antibody also labels dendritic cells, granulocytes andmicrogliain the brain (Robinsonet al.1986).Mouse anti Rat CD11b, clone OX-42 is reported to inhibit complement mediated rosettes (Robinsonet al.1986) as well as inhibit myelin binding and uptake (van der Laanet al.1996). |
| 产品详情 | | |
| Target Species | Rat |
| Product Form | Purified IgG - liquid |
| Preparation | Purified IgG prepared by affinity chromatography on Protein G from tissue culture supernatant |
| Buffer Solution | Phosphate buffered saline |
| Immunogen | Resident rat peritoneal macrophages. |
| Fusion Partners | Spleen cells from immunised BALB/c mice were fused with cells of the NSO/U mouse myeloma cell line. |
| Preservative Stabilisers | 0.09%Sodium Azide |
| Approx. Protein Concentrations | IgG concentration 1.0 mg/ml |
| Regulatory | For research purposes only |
| Guarantee | 12 months from date of despatch |
| 存储条件 | | |
| This product is shipped at ambient temperature. It is recommended to aliquot and store at -20°C on receipt. When thawed, aliquot the sample as needed. Keep aliquots at 2-8°C for short term use (up to 4 weeks) and store the remaining aliquots at -20°C.Avoid repeated freezing and thawing as this may denature the antibody. Storage in frost-free freezers is not recommended. |
| 应用 | | |
| Application Name | Verified | Min Dilution | Max Dilution |
| Flow Cytometry | √ | 1/50 | |
| This product has been reported to work in the following applications. This information is derived from testing within our laboratories, peer-reviewed publications or personal communications from the originators. Please refer to references indicated for further information. For general protocol recommendations, please visit theantibody protocolspage.Where this antibody has not been tested for use in a particular technique this does not necessarily exclude its use in such procedures. Suggested working dilutions are given as a guide only. It is recommended that the user titrates the antibody for use in their own system using appropriate negative/positive controls. |
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| Goat anti Mouse IgG (H/L):Alk. Phos. (Multi Species Adsorbed) | STAR117A | F | 0.5mg |
| 文献 |
| 1.Stidworthy, M.F.et al.(2004) Notch1 and Jagged1 are expressed after CNS demyelination, but are not a major rate-determining factor during remyelination.Brain, 127: 1928-41.2.Baca Jones, C.C. (2009) Rat cytomegalovirus infection depletes MHC II in bone marrow derived dendritic cells.Virology. 388: 78-90.3.Clark, A.K.et al(2007) Inhibition of spinal microglial cathepsin S for the reversal of neuropathic pain.Proc Natl Acad Sci U S A. 104: 10655-60.4.Draskovic-Pavlovic, B.et al.(1999) Differential effects of anti-rat CD11b monoclonal antibodies on granulocyte adhesiveness.Immunology. 96: 83-9. |
技术参数 产品应用 Flow
产品类型 Monoclonal Antibody
推荐用于 Flow
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