Rat anti Mouse CD4: StarBright Violet 670

货号：MCA2691SBV670

规格：100 Tests/0.5ml

价格：4063

产品类型：流式抗体

品牌：Bio-Rad

抗原：CD4

物种：小鼠

宿主：大鼠

抗体亚型：IgG2a

克隆号：RM4-5

荧光染料：StarBright Violet 670

类型:	单抗	同型对照：	IgG2a
浓度：		用法：	5 µL/test(Flow)
免疫原性：	BALB/c mouse thymocytes

Rat anti Mouse CD4 antibody, clone RM4-5detects mouse CD4, a 55 kDa protein also known as Ly-4 and L3T4. CD4 is a single chain transmembraneous glycoprotein which belongs to the immunoglobulin superfamily, and is primarily expressed on peripheral blood monocytes and tissue macrophages. CD4 is also expressed on a subpopulation of regulatory T cells (CD4+CD25+), which play a key role in the maintenance of self tolerance.Rat anti Mouse CD4 antibody, clone RM4-5 can be used forin vitroblocking of ligand binding, as well asin vitroCD4+ T cell depletions.

数据

Figure A. Alexa Fluor 647 conjugated Rat anti Mouse CD3 (MCA500A647). Figure B. Alexa Fluor 647 conjugated Rat anti Mouse CD4 (MCA500A647) and StarBright Violet 670 conjugated Rat anti Mouse CD4 (MCA2691SBV670). All experiments performed on red cell lysed mouse blood gated on live single lymphocytes, in the presence of 10% mouse serum. Data acquired on the ZE5 Cell Analyzer.

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参考文献：

1. Fehérvari, Z. & Sakaguchi, S. (2004) CD4+ Tregs and immune control.J Clin Invest. 114 (9): 1209-17.2. von Kutzleben, S.et al.(2017) Depletion of CD52-positive cells inhibits the development of central nervous system autoimmune disease, but deletes an immune-tolerance promoting CD8 T-cell population. Implications for secondary autoimmunity of alemtuzumab in multiple sclerosis.Immunology. 150 (4): 444-55.3. Zamudio, F.et al.(2020) TDP-43 mediated blood-brain barrier permeability and leukocyte infiltration promote neurodegeneration in a low-grade systemic inflammation mouse model.J Neuroinflammation. 17 (1): 283.

技术参数

产品应用 Flow

产品类型 单克隆抗体

推荐用于 Flow

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