| 产品介绍 | | |
| Rabbit anti Human 5-HT& receptor antibodyrecognizes the N-terminal region of the serotonin (5-hydroxytryptamine, 5-HT) receptor 5-HT7, which belongs to the G-protein coupled receptor superfamily. Serotonin is a neurotransmitter and vasoactive amine which is thought to play a role in various cognitive and behavioural functions including pain, appetite, mood and sleep.Signalling through 5-HT7has several effects, including regulation of the circadian rhythm and mediation of smooth-muscle relaxation in the vasculature and gastrointestinal tract. Signalling though 5-HT7has also been shown to contribute to early T-cell activation.5-HT7has been implicated in depression, autism, and other neuropsychiatric disorders. |
| 产品详情 | | |
Target Species | Human |
Product Form | Purified IgG - liquid |
Antiserum Preparation | Antisera to 5-HT7 receptor (NT) were raised by repeated immunisations of rabbits with highly purified antigen. Purified IgG prepared by affinity chromatography. |
Buffer Solution | Phosphate buffered saline |
Preservative Stabilisers | <0.1% Sodium Azide (NaN3) |
Approx. Protein Concentrations | IgG concentration 0.5mg/ml |
Immunogen | Synthetic peptide corresponding to the N-terminal domain of human 5-HT7 receptor, conjugated to Keyhole Limpet Hemocyanin (KLH). |
Regulatory | For research purposes only |
Guarantee | 12 months from date of despatch |
| 存储条件 | | |
| This product is shipped at ambient temperature. It is recommended to aliquot and store at -20°C on receipt. When thawed, aliquot the sample as needed. Keep aliquots at 2-8°C for short term use (up to 4 weeks) and store the remaining aliquots at -20°C.Avoid repeated freezing and thawing as this may denature the antibody. Storage in frost-free freezers is not recommended. |
| 应用 | | |
Application Name | Verified | Min Dilution | Max Dilution |
Immunohistology - Paraffin1 | √ | | 10ug/ml |
This product has been reported to work in the following applications. This information is derived from testing within our laboratories, peer-reviewed publications or personal communications from the originators. Please refer to references indicated for further information. For general protocol recommendations, please visit theantibody protocolspage.1This product requires antigen retrieval using heat treatment prior to staining of paraffin sections.Sodium citrate buffer pH 6.0 is recommended for this purpose.Where this product has not been tested for use in a particular technique this does not necessarily exclude its use in such procedures. Suggested working dilutions are given as a guide only. It is recommended that the user titrates the product for use in their own system using appropriate negative/positive controls.- Histology Positive Control Tissue
- Brain, cortex.
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| 数据 |
Staining of formalin fixed, paraffin embedded human brain cortex with Rabbit anti Human 5_HT7 receptor (AHP1344). |
| 文献 |
| 1. León-ponte, M.et al.(2007) Serotonin provides an accessory signal to enhance T-cell activation by signaling through the 5-HT7 receptor.Blood. 109 (8): 3139-46.2. Soll, C.et al.(2012) Expression of serotonin receptors in human hepatocellular cancer.Clin Cancer Res. 18: 5902-10. |
QQ:1749072012