Sheep anti human C5 polyclonal antibody
货号：2222-8354
规格：1 ml
价格：4123
产品类型：免疫组化一抗
品牌：Bio-Rad
抗原：C5 polyclonal
物种：人
宿主：Sheep
抗体亚型：IgG
荧光染料：Purified
| 产品介绍 | | |
| Sheep anti human C5 polyclonal antibodyrecognizes complement component 5 (C5), a member of the complement system. The complement system consists of a tightly regulated network of proteins. Its activation leads to a sequential cascade of enzymatic reactions, resulting in opsonisation of the pathogens and their removal by phagocytes, as well as cell lysis. Three pathways have been described, the antibody-dependent pathway (classical pathway), the alternative pathway and the lectin activation pathway (Ehrnthaller 2011,Nesargikar 2012). The complement system plays a critical role in both innate and adaptive immune responses. It is also involved in tissue regeneration, tumor growth and some human pathologies (Sarma 2011).Complement component 5 is the initiator of the effector terminal phase of the complement system. C5 convertase cleaves C5 into C5a, a potent anaphylatoxin, and C5b, ultimately resulting in the formation of the multimeric membrane attack complex (MAC) together with the other components of the terminal pathway (C5b-C9) (Noris 2013).Sheep anti human polyclonal antibody gives a single arc when tested by immunoelectrophoresis (IEP) against human plasma. The identity has been confirmed by double diffusion against fresh human plasma and a known anti human C5. |
| 产品详情 | | |
Target Species | Human |
Product Form | Ig fraction - liquid |
Preparation | Ig fraction prepared by ion exchange chromatography |
Buffer Solution | Glycine buffered saline |
Preservative Stabilisers | 0.09%Sodium Azide(NaN3) 0.1%E-amino-n-caproic acid (EACA) 0.01%Benzamidine1 mMethylenediaminetetraacetic acid (EDTA) |
Immunogen | Human C5, purified from plasma. |
Regulatory | For research purposes only |
Guarantee | Guaranteed until date of expiry. Please see product label. |
| 存储条件 | | |
| This product is shipped at ambient temperature. It is recommended to aliquot and store at -20°C on receipt. When thawed, aliquot the sample as needed. Keep aliquots at 2-8°C for short term use (up to 4 weeks) and store the remaining aliquots at -20°C.Avoid repeated freezing and thawing as this may denature the antibody. Storage in frost-free freezers is not recommended. |
| 应用 | | |
Application Name | Verified | Min Dilution | Max Dilution |
Immunodiffusion | √ | | |
Immunohistology - Paraffin | √ | | 1/100 |
| This product has been reported to work in the following applications. This information is derived from testing within our laboratories, peer-reviewed publications or personal communications from the originators. Please refer to references indicated for further information. For general protocol recommendations, please visit theantibody protocolspage.Where this product has not been tested for use in a particular technique this does not necessarily exclude its use in such procedures. Suggested working dilutions are given as a guide only. It is recommended that the user titrates the product for use in their own system using the appropriate negative/positive controls. |
| 二抗相关产品 |
Description | Product Code | Applications | Pack Size |
| Rabbit anti Sheep IgG (H/L):Biotin | 5184-2304 | C;E;F;WB | 1.5 ml |
| Donkey anti Sheep/Goat IgG:DyLight®488 | STAR88D488GA | F;IF | 0.1 mg |
| Donkey anti Sheep/Goat IgG:HRP | STAR88P | C;E;P;WB | 1 ml |
| 数据 |
Sheep anti Human C5 antibody (2222-8354) used to demonstrate C5 expression in human liver by immunohistochemistry on formalin fixed, paraffin embedded tissue sections. Detection was with biotinylated anti sheep IgG and alkaline phosphatase conjugated streptavidin (red). Nuclei are counterstained with hematoxylin (blue). |
技术参数 产品应用 ID;IHC(P)
产品类型 Polyclonal Antibody
推荐用于 ID;IHC(P)
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