Applications

FA

Synonyms:

GW 2580, 5-(3-methoxy-4-((4-methoxybenzyl)oxy)benzyl)pyrimidine-2,4-diamine

Formulation:

Crystalline solid

Chemical Name:

5-[[3-methoxy-4-[(4-methoxyphenyl)methoxy]phenyl]methyl]pyrimidine-2,4-diamine

Molecular Formula:

C₂₀H₂₂N₄O₃

Molecular Weight:

366.4

CAS Number

870483-87-7

Purity:

≥98%

Storage Conditions:

Product should be kept at -20°C.

References:

Conway, J. G., McDonald, B., Parham, J., Keith, B., Rusnak, D. W., Shaw, E., ... & Hutchins, J. T. (2005). Inhibition of colony-stimulating-factor-1 signaling in vivo with the orally bioavailable cFMS kinase inhibitor GW2580.Proceedings of the National Academy of Sciences of the United States of America,102(44), 16078-16083.

Xu, J., Escamilla, J., McBride, W., & Wu, L. (2011). Abstract C227: Blockade of tumor-infiltrating myeloid cells by inhibiting CSF-1 receptor overcomes tumor recurrence after radiation therapy.Molecular Cancer Therapeutics,10(11 Supplement), C227-C227.

Komohara, Y., Hasita, H., Ohnishi, K., Fujiwara, Y., Suzu, S., Eto, M., & Takeya, M. (2011). Macrophage infiltration and its prognostic relevance in clear cell renal cell carcinoma.Cancer science,102(7), 1424-1431.