Applications

FA

Synonyms:

SB216763, SB-216763, SCHEMBL30251

Formulation:

Crystalline solid

Chemical Name:

3-(2,4-dichlorophenyl)-4-(1-methylindol-3-yl)pyrrole-2,5-dione

Molecular Formula:

C₁₉H₁₂Cl₂N₂O₂

Molecular Weight:

371.2

CAS Number

280744-09-4

Purity:

≥98%

Storage Conditions:

Product should be kept at -20°C.

References:

Gross, E. R., Hsu, A. K., & Gross, G. J. (2008). Delayed cardioprotection afforded by the glycogen synthase kinase 3 inhibitor SB-216763 occurs via a KATP-and MPTP-dependent mechanism at reperfusion.American Journal of Physiology-Heart and Circulatory Physiology,294(3), H1497-H1500.

Coghlan, M. P., Culbert, A. A., Cross, D. A., Corcoran, S. L., Yates, J. W., Pearce, N. J., ... & Holder, J. C. (2000). Selective small molecule inhibitors of glycogen synthase kinase-3 modulate glycogen metabolism and gene transcription.Chemistry & biology,7(10), 793-803.

Kirby, L. A., Schott, J. T., Noble, B. L., Mendez, D. C., Caseley, P. S., Peterson, S. C., ... & Patel, N. V. (2012). Glycogen synthase kinase 3 (GSK3) inhibitor, SB-216763, promotes pluripotency in mouse embryonic stem cells.PloS one,7(6), e39329.