Human GDF-15/MIC-1
货号：120-28-100,120-28-1000,120-28-20,120-28-200,120-28-5,120-28-500
规格：100ug,1mg,20ug,200ug,5ug,500ug
价格：17320,120120,2570,34650,1050,75070
产品类型：细胞因子添加物
品牌：PeproTech
| 产品描述：GDF-15 belongs to the TGF-β cytokine family, whose members play an important role during prenatal development and postnatal growth, and the remodeling and maintenance of a variety of tissues and organs. GDF-15 is expressed predominantly in the placenta and, to a much lesser extent, in various other tissues. The presence of GDF-15 in amniotic fluid and its elevated levels in the sera of pregnant women suggest GDF-15's involvement in gestation and embryonic development. GDF-15 generally exerts tumor suppressive activities and is one of the predominant factors produced and secreted in response to activation of the p53 pathway. Interestingly, the serum level of GDF-15 is positively correlated with neoplastic progression of several tumor types, including certain colorectal, pancreatic, and prostate cancers. Human GDF-15/MIC-1 is a disulfide linked homodimeric protein consisting of two 112 amino acid polypeptide chains. The calculated molecular weight of Human GDF-15/MIC-1 is 24.6 kDa.来源:Cell Culture别名:Growth/Differentiation Factor-15, MIC-1, Macrophage Inhibitory Cytokine 1, Placental TGFβ, Prostate Differentiation Factor氨基酸序列:ARNGDHCPLG PGRCCRLHTV RASLEDLGWA DWVLSPREVQ VTMCIGACPS QFRAANMHAQ IKTSLHRLKP DTVPAPCCVP ASYNPMVLIQ KTDTGVSLQT YDDLLAKDCH CI纯度:≥ 98% by SDS-PAGE gel and HPLC analyses.Biological Activity:Determined by its ability to inhibit alkaline phosphatase activity in differentiating MC3T3/E1 osetoblast cells. The expectedED50for this effect is 1.0-3.0 μg/ml.Calculated Molecular Weight:24.6 kDaAccession Number:Q99988Gene ID:9518交叉反应：Human,Mouse |
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