Animal-Free Recombinant Murine Noggin
货号：AF-250-38-5,AF-250-38-20,AF-250-38-50,AF-250-38-100,AF-250-38-250,AF-250-38-500,AF-250-38-1000
规格：5µg,20ug,50ug,100ug,250ug,500ug,1mg
价格：582,2830,9930,16550,28960,43040,66220
产品类型：细胞因子添加物
品牌：PeproTech
| 产品描述：Noggin belongs to a group of diffusible proteins that bind to ligands of the TGF-β family, and regulate their activity by inhibiting their access to signaling receptors. Noggin was originally identified as a BMP-4 antagonist whose action was critical for proper formation of the head and other dorsal structures. Consequently, noggin has been shown to modulate the activities of other BMPs including BMP-2,-7,-13, and -14. Targeted deletion of noggin in mice results in prenatal death, and a recessive phenotype displaying a severely malformed skeletal system. Conversely, transgenic mice over-expressing noggin in mature osteoblasts display impaired osteoblastic differentiation, reduced bone formation, and severe osteoporosis. Recombinant Murine Noggin is a 46.4 kDa disulfide-linked homodimer consisting of two 206 amino acid polypeptide chains.Manufactured using all Animal-Free reagents.来源:E.coli别名:None氨基酸序列:MQHYLHIRPA PSDNLPLVDL IEHPDPIFDP KEKDLNETLL RSLLGGHYDP GFMATSPPED RPGGGGGPAG GAEDLAELDQ LLRQRPSGAM PSEIKGLEFS EGLAQGKKQR LSKKLRRKLQ MWLWSQTFCP VLYAWNDLGS RFWPRYVKVG SCFSKRSCSV PEGMVCKPSK SVHLTVLRWR CQRRGGQRCG WIPIQYPIIS ECKCSC纯度:≥ 98% by SDS-PAGE gel and HPLC analyses.生物活性:Determined by its ability to inhibit 5.0 ng/ml of BMP-4 induced alkaline phosphatase production by ATDC5 chondrogenic cells. The expectedED50for this effect is 1.0-2.0 ng/ml of Noggin.Calculated Molecular Weight:46.4 kDaAccession Number:P97466Gene ID:18121交叉反应:Human,Mouse原产国:USA |
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