Recombinant Human IL-13 Variant
货号：200-13A-10,200-13A-100,200-13A-1000,200-13A-2,200-13A-250,200-13A-500
规格：10ug,100ug,1mg,2ug,250ug,500ug
价格：1425,11123,44543,585,19450,28897
产品类型：细胞因子添加物
品牌：PeproTech
| 产品描述：IL-13 is an immunoregulatory cytokine produced primarily by activated Th2 cells, and also by mast cells and NK cells. Targeted deletion of IL-13 in mice resulted in impaired Th2 cell development and indicated an important role for IL-13 in the expulsion of gastrointestinal parasites. IL-13 exerts anti-inflammatory effects on monocytes and macrophages and it inhibits the expression of inflammatory cytokines such as IL-1β, TNF-α, IL-6 and IL-8. IL-13 has also been shown to enhance B cell proliferation and to induce isotype switching, resulting in increased production of IgE. Blocking of IL-13 activity inhibits the pathophysiology of asthma. Human and murine IL-13 are cross-species reactive. A variant of IL-13 shows enhanced functional activity compared with the wild type IL-13. PeproTech’s genetic variant, termed Recombinant Human IL-13 Variant, is a mature 115 amino acid protein with a substitution of Q for R at position 113. The calculated molecular weight of Recombinant Human IL-13 Variant is 12.6 kDa.来源:E.coli别名:None氨基酸序列:MSPGPVPPST ALRELIEELV NITQNQKAPL CNGSMVWSIN LTAGMYCAAL ESLINVSGCS AIEKTQRMLS GFCPHKVSAG QFSSLHVRDT KIEVAQFVKD LLLHLKKLFR EGQFN纯度:≥ 98% by SDS-PAGE gel and HPLC analyses.生物活性:This IL-13 analog shows a two fold increase, relative to wild type IL-13, in bioactivity as measured by thein-vitrodose dependent activation of STAT6 and IL-13 dependent gene induction in transfected A201.1 cells. This analog has also been shown to exhibit increasedin vivoactivity compared to wild type IL-13, as measured by the induction of airway hyper-responsiveness.Calculated Molecular Weight:12.6 kDaAccession Number:P35225Gene ID:3596交叉反应：Human,Mouse原产国:USA |
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