CD19MonoclonalAntibodyMB19-1FITCeBioscience
货号：11-0191-82,11-0191-85,11-0191-81
规格：100 ug,500 ug,50 ug
价格：1677,3037,0
产品类型：流式抗体
品牌：eBioscience
抗原：CD19
物种：小鼠
宿主：小鼠
抗体亚型：IgG
克隆号：MB19-1
荧光染料：FITC
tablewidth750stylewidth684pxdata-sortsortDisabledtbodytrclassfirstRowtdwidth77aligncentervalignmiddlestyleborder-width1pxborder-colorrgb216216216border-right-stylesolidborder-bottom-stylesolid-ms-word-breakbreak-allbackground-colorrgb242242242h4stylemargin-top5pxmargin-bottom5pxstrongstylefont-size14px抗体类型strongh4tdtdwidth247aligncentervalignmiddlestyleborder-width1pxborder-colorrgb216216216border-right-stylesolidborder-bottom-stylesolid-ms-word-breakbreak-allbackground-colorrgb242242242h4stylemargin-top5pxmargin-bottom5pxspanstylefont-size14px流式抗体spanh4tdtdwidth79aligncentervalignmiddlestyleborder-width1pxborder-colorrgb216216216border-right-stylesolidborder-bottom-stylesolid-ms-word-breakbreak-allbackground-colorrgb242242242h4stylemargin-top5pxmargin-bottom5pxspanstylefont-size14pxstrongstylewhite-spacenormal同型对照strongspanh4tdtdwidth279aligncentervalignmiddlestyleborder-width1pxborder-colorrgb216216216border-right-stylesolidborder-bottom-stylesolid-ms-word-breakbreak-allbackground-colorrgb242242242h4stylemargin-top5pxmargin-bottom5pxspanstylefont-size14pxnbspspanh4tdtrtrtdwidth78aligncentervalignmiddlestyleborder-width1pxborder-colorrgb216216216border-right-stylesolidborder-bottom-stylesolid-ms-word-breakbreak-allbackground-colorrgb242242242rowspan1colspan1h4stylemargin-top5pxmargin-bottom5pxspanstylefont-size14px浓度spanh4tdtdwidth247aligncentervalignmiddlestyleborder-width1pxborder-colorrgb216216216border-right-stylesolidborder-bottom-stylesolid-ms-word-breakbreak-allbackground-colorrgb242242242rowspan1colspan1h4stylemargin-top5pxmargin-bottom5pxwhite-spacenormalspanstylefont-size14pxnbsp05mgmLspanh4tdtdwidth79aligncentervalignmiddlestyleborder-width1pxborder-colorrgb216216216border-right-stylesolidborder-bottom-stylesolid-ms-word-breakbreak-allbackground-colorrgb242242242rowspan1colspan1h4stylemargin-top5pxmargin-bottom5pxstrongspanstylefont-size14px用法spanstrongh4tdtdwidth279aligncentervalignmiddlestyleborder-width1pxborder-colorrgb216216216border-right-stylesolidborder-bottom-stylesolid-ms-word-breakbreak-allbackground-colorrgb242242242rowspan1colspan1h4stylemargin-top5pxmargin-bottom5pxwhite-spacenormalspanstylefont-size14px1gtestFlowspanh4tdtrtbodytablepnbspnbspnbspnbspspanstylefont-size14pxspanptablewidth750stylewidth684pxdata-sortsortDisabledtbodytrclassfirstRowtdalignleftvalignmiddlestyleborder1pxsolidrgb216216216border-imagenonebackground-colorrgb255255255rowspan1colspan6h4stylemargin-top5pxmargin-bottom5pxspanstylefont-size14px产品详细信息nbspspanbrh4h4stylemargin-top5pxmargin-bottom5pxspanstylefont-size14pxDescriptionTheMB19-1monoclonalantibodyreactswithmouseCD19a95kDatransmembraneglycoproteinCD19isexpressedbyBcellsduringallstagesofdevelopmentexcludingtheterminallydifferentiatedplasmacellsFolliculardendriticcellsalsoexpressCD19TogetherCD21CD81MHCclassIIandCD19formamultimolecularcomplexthatassociateswiththeBCRSignalingthroughCD19inducestyrosinephosphorylationcalciumfluxandproliferationofBcellsStainingofBcellswithMB19-1anditsconjugatesisusuallydimmerthantheratanti-mouseCD19antibodyclone6D5brstylebox-sizingborder-boxApplicationsReportednbspTheMB19-1antibodyhasbeenreportedforuseinflowcytometricanalysisbrstylebox-sizingborder-boxApplicationsTestedTheMB19-1antibodyhasbeentestedbyflowcytometricanalysisofmousesplenocytesThiscanbeusedatlessthanorequalto1gpertestAtestisdefinedastheamountgofantibodythatwillstainacellsampleinafinalvolumeof100LCellnumbershouldbedeterminedempiricallybutcanrangefrom105to108cellstestItisrecommendedthattheantibodybecarefullytitratedforoptimalperformanceintheassayofinterestbrstylebox-sizingborder-boxExcitation488nmEmission520nmLaserBlueLaserbrstylebox-sizingborder-boxFiltration02mpost-manufacturingfilterednbspspanbrh4h4stylemargin-top5pxmargin-bottom5pxspanstylefont-size14px靶标信息nbspspanbrh4h4stylemargin-top5pxmargin-bottom5pxspanstylefont-size14pxCD19isamemberoftheimmunoglobulinsuperfamilyandhastwoIglikedomainsTheCD19moleculeisexpressedon100oftheperipheralBcellsasdefinedbyexpressionofkappaorlambdalightchainsCD19appearstobeexpressedonmyeloidleukemiacellsparticularlythoseofmonocyticlineageLeukemiaphenotypestudieshavedemonstratedthattheearliestandbroadestBcellrestrictedantigenistheCD19antigenThereceptorforCD19isanimportantfunctionalregulatorofnormalandmalignantBcellproliferationandisexpressedinallBcellprecursorleukemiasLymphocytesproliferateanddifferentiateinresponsetovariousconcentrationsofdifferentantigensTheabilityoftheBcelltorespondinaspecificyetsensitivemannertothevariousantigensisachievedwiththeuseoflow-affinityantigenreceptorsCD19isacellsurfacemoleculewhichassembleswiththeantigenreceptorofBlymphocytesinordertodecreasethethresholdforantigenreceptor-dependentstimulationBesidesbeingasignal-amplifyingcoreceptorfortheBcellreceptorBCRCD19canalsosignalindependentlyofBCRco-ligationandisacentralregulatorycomponentuponwhichmultiplesignalingpathwaysconvergeMutationoftheCD19generesultsinhypogammaglobulinemiawhereasCD19overexpressioncausesBcellhyperactivityspanbrh4tdtrtrtdalignleftvalignmiddles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