CD26 Monoclonal Antibody (2A6), FITC, eBioscience™
货号：11-0269-42
规格：100 Tests
价格：2243
产品类型：流式抗体
品牌：eBioscience
抗原：CD26
物种：人
宿主：小鼠
抗体亚型：IgG1, kappa
克隆号：2A6
荧光染料：FITC
| 抗体类型: | 单抗 | 同型对照： | Mouse IgG1 kappa Isotype Control, FITC, eBioscience™ |
| 浓度： | 5 µL/Test | 用法： | 5uL（1 µg）/test(Flow） |
产品详细信息Description: The 2A6 monoclonal antibody reacts with human CD26, a 110 kDa type II transmembrane dimer. CD26 is an ectoenzyme with dipeptidyl peptidase IV activity expressed by T cells and is upregulated upon T cell stimulation. It is thought that CD26 plays a role in interaction with the extracellular matrix molecules and in T cell activation.Applications Reported: The 2A6 antibody has been reported for use in flow cytometric analysis.Applications Tested: This 2A6 antibody hasbeen pre-titrated and tested by flow cytometric analysis of normal human peripheral blood cells. This can be used at 5 µL (1 µg) per test. A test is defined as the amount (µg) of antibody that will stain a cell sample in a final volume of 100 µL. Cell number should be determined empirically but can range from 10^5 to 10^8 cells/test.Excitation: 488 nm; Emission: 520 nm; Laser: Blue Laser.Filtration: 0.2 µm post-manufacturing filtered.靶标信息CD26 (dipeptidyl peptidase IV, DPP IV), adenosine deaminase (ADA) binding protein) is a homodimeric atypical serine protease belonging to the prolyl oligopeptidase family. CD26 is expressed on lymphocyte cells and is upregulated during T-cell activation. CD26 is also expressed on activated B cells and natural killer cells and abundantly on epithelia. CD26 is implicated in a variety of biological functions including T-cell activation, cell adhesion with extracellular matrix such as fibronectin orcollagens, and in HIV infection. Cross-linking of CD26 using this antibody dramatically enhances the anti CD3-induced IL - 2 production. CD26 identical to adenosine deaminase complexing protein-2, and to the T-cell activation antigen CD26. Further, CD26 is an intrinsic membrane glycoprotein and a serine exopeptidase that cleaves X-proline dipeptides from the N-terminus of polypeptides. Alterations in CD26 peptidase activity are characteristic of malignant transformation, and the enzymatic activity increases dramatically with tumor grade and severity. CD26 is expressed in various blood cell types, but also in cells that are histogenetically related to activated fibroblasts. Alterations in CD26 density have been reported on circulating monocytes and CD4+ T cells during rheumatoid arthritis and systemic lupus erythematosus.
| 数据 |
| CD26 Antibody (11-0269-42) in FlowStaining of normal human peripheral blood cells with Anti-Human CD26 FITC (left)and PE (right). Appropriate isotype controls were used (open histogram).Cells in the lymphocyte gate were used for analysis. |
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