CD278 (ICOS) Monoclonal Antibody (7E.17G9), APC
货号：17-9942-82,17-9942-80
规格：100μg,25μg
价格：2613,1099
产品类型：流式抗体
品牌：Thermo Fisher
物种：小鼠
宿主：大鼠
抗体亚型：IgG2b, kappa
克隆号：7E.17G9
荧光染料：APC
抗体类型: | 单抗 | 同型对照： | IgG2b, kappa |
免疫原性： | | 用法： | 0.5µg/test(Flow） |
Description: The 7E.17G9 monoclonal antibody reacts with mouse ICOS (Inducible COStimulatory molecule), a T cell specific molecule and a third member of the CD28/CTLA-4 family. A homodimer of 47-57 kDa, ICOS is expressed on activated T cells, has potent costimulatory activity for T cell activation and proliferation and is required for humoral immune response. ICOS binds to its ligand on activated APC including B cells called B7h/B7RP-1 and is thought to play a protective role in inflammatory autoimmune diseases. ICOS may be involved in the development of Th2 cells.Applications Reported: This 7E.17G9 antibody has been reported for use in flow cytometric analysis.Applications Tested: This 7E.17G9 antibody has been tested by flow cytometric analysis of stimulated mouse splenocytes. This can be used at less than or equal to 0.5 µg per test. A test is defined as the amount (µg) of antibody that will stain a cell sample in a final volume of 100 µL. Cell number should be determined empirically but can range from 10^5 to 10^8 cells/test. It is recommended that the antibody be carefully titrated for optimal performance in the assay of interest.Excitation: 633-647 nm; Emission: 660 nm; Laser: Red LaserBackground/Target InformationCD278 belongs to the CD28 and CTLA-4 cell-surface receptor family and is highly expressed in activated T-cells. It is essential both for efficient interaction between T and B-cells and for normal antibody responses to T-cell dependent antigens. It enhances all basic T-cell responses to a foreign antigen, namely proliferation, secretion of lymphokines, up-regulation of molecules that mediate cell-cell interaction, and effective help for antibody secretion by B-cells.For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
数据 |
| CD278 (ICOS) Antibody (17-9942-82) in Flow Staining of unstimulated (left) or 3-day Con A (Product # 00-4978-93)-stimulated (right) mouse splenocytes with Anti-Mouse CD25 PE (Product # 12-0251-82) and 0.25 µg of Anti-Mouse CD278 (ICOS) APC. Total viable cells were used for analysis. Quadrant lines were based on staining with 0.25 µg of Rat IgG2b K Isotype Control APC (Product # 17-4031-82). |
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