IL-20RB Monoclonal Antibody (20RNTC)
货号：14-1206-80,14-1206-82
规格：25μg,100μg
价格：0,2684
产品类型：流式抗体
品牌：Thermo Fisher
物种：人
宿主：大鼠
抗体亚型：IgG2a, kappa
克隆号：20RNTC
荧光染料：其它
抗体类型: | 单抗 | 同型对照： | IgG2a, kappa |
免疫原性： | | 用法： | 1-10 µg/mL(flow);Assay-Dependent(ICC);Assay-Dependent(IF);Assay-Dependent（WB） |
Description: This 20RNTC monoclonal antibody recognizes mouse and human IL-20R2 (interleukin-20 receptor 2, IL-20Rb) in either of its two heterodimeric complexes formed by pairing with IL-20R1 or IL-22R1. IL-20R2 belongs to the class II cytokine receptor family that shares a characteristic pattern of cysteine, proline and tryptophan residues in the extracellular domain. IL-20R2 paired with IL-20R1 forms a receptor that binds IL-20, IL-19, or IL-24. IL-20R2 paired with IL22R1 forms a receptor that binds IL-20 or IL-24. The IL-20R complex signals primarily via the JAK-STAT pathway. IL-20R2 is found predominantly on cells of epithelial origin such as gut and skin and can be upregulated during inflammation. Immunofluorescent staining of A375 cells reveals a punctate staining pattern at the cell membrane, as well as diffuse, cytoplasmic staining that is likely associated with protein synthesis and transport in the endoplasmic reticulum and golgi.Applications Reported: This 20RNTC antibody has been reported for use in immunocytochemistry, immunoblotting (WB) and flow cytometric analysis.Applications Tested: This 20RNTC antibody has been tested by immunofluorescent staining and flow cytometric analysis of fixed and permeabilized A375 cells. This can be used between 1-10 µg/mL.Purity: Greater than 90%, as determined by SDS-PAGE.Aggregation: Less than 10%, as determined by HPLC.Filtration: 0.2 µm post-manufacturing filtered.Background/Target InformationIL20RB and IL20RA (MIM 605620) form a heterodimeric receptor for interleukin-20 (IL20; MIM 605619) (Blumberg et al., 2001 [PubMed 11163236]).[supplied by OMIM, Feb 2009].For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
数据 |
| IL-20RB Antibody (14-1206-82) in IF Immunofluorescent microscopy of fixed and permeabilized A375 cells using 10 µg/mL of Anti-Human/Mouse IL-20 Receptor 2 (IL-20Rb) Purified (right) or Rat IgG2a kappa Isotype Control Purified (Product # 14-4321-82) (left) followed by Anti-Rat IgG Biotin (Product # 13-4813-85) and then Streptavidin FITC (Product # 11-4317-87). |
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参考文献： |
| 1.Nature immunologySignaling via the IL-20 receptor inhibits cutaneous production of IL-1β and IL-17A to promote infection with methicillin-resistant Staphylococcus aureus."14-1206 was used in Neutralization experiments to identify an immunosuppressive role for IL-19, IL-20 and IL-24 during Staphylococcus aureus infection."AuthorsMyles IA,Fontecilla NM,Valdez PA,Vithayathil PJ,Naik S,Belkaid Y,Ouyang W,Datta SK |
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