RAB11A Antibody, Alexa Fluor 488 (3H18L5), ABfinity™ Rabbit Monoclonal
货号：MA7-00184-A488
规格：50 µl
价格：4223
产品类型：流式抗体
品牌：Thermo Fisher
物种：人
宿主：兔
抗体亚型：IgG
荧光染料：Alexa Fluor 488
类型: | 单抗 | 同型对照： | IgG |
免疫原性： | A peptide corresponding to amino acids 179-194 of human Rab11. | 用法： | 1-10 µg/mL(IF);1-10 µg/mL(ICC) |
Product Specific InformationThis antibody is predicted to react with bovine, chicken, equine, mouse, primate, rat, Xenopus and zebrafish based on sequence homologyABfinity™ recombinant antibodies are rabbit monoclonal antibodies, unmatched for producing superior results. ABfinity™ antibodies are developed by immunizing animals, screening for functionality, cloning the immunogen-specific antibody genes into high-level mammalian expression vectors, produced on a large scale, and purified with Protein A.ABfinity™ monoclonal antibodies resemble rabbit monoclonals isolated from serum or produced by hybridomas, but demonstrate greater specificity and sensitivity. Because ABfinity™ recombinant antibodies are derived from cloned DNA sequences of the heavy and light antibody chains, they are not susceptible to cell-line drift or lot-to-lot variation, thus allowing for peak specificity and performance.Target InformationRab11A is a member of the YPT-1 subfamily of Ras-related GTP-binding proteins. Rab11A mRNA has been detected in a variety of tissues including brain, testis, spleen, heart, and gastrointestinal mucosa. In the gastric fundus the Rab11A protein is expressed in parietal cell tubulovesicles membranes. Expression of the Rab11A protein appears to occur in discrete epithelial cell populations where it localizes to apical vesicular populations. Recent studies have shown Rab11A is essential for resecretion of alpha-synuclein out of neuronal cells via endosome recycling and is required for exocytosis of discoidal/fusiform vesicles of bladder umbrella cells. Rab11A is also implicated in biogenesis of Birbeck granules and endosomal activation of the PI3K/AKT signaling pathway via G beta gamma trafficking.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
数据 |
| RAB11A Antibody (MA7-00184-A488) in IFImmunofluorescent analysis of Rab11 (green) in HeLa cells. The cells were fixed with 4% Paraformaldehyde in PBS for 15 minutes at room temperature, and blocked with 3% BSA in PBS (Product # 37525) for 30 minutes at room temperature. Cells were stained with a Rab11 Monoclonal Antibody, AlexaFluor 488 conjugate (Product # MA7-00184-A488) at a dilution of 5 µg/mL in blocking buffer for 1 hour at room temperature protected from light. Nuclei (blue) were stained with Hoechst Dye (Product # 62249) at a dilution of 1:10,000 in blocking buffer. Images were taken on a Thermo Scientific ToxInsight Instrument at 20X magnification. |
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