TIM-1 (HAVCR1) Mouse ELISA Kit/小鼠TIM-1 (HAVCR1) ELISA试剂盒
货号：EMHAVCR1,EMHAVCR1X5,EMHAVCR1X10
规格：96 tests,5X96 tests,10X96 tests
价格：7238,29891,52892
产品类型：Platinum ELISA
品牌：Thermo Fisher
物种：小鼠
宿主：其它
抗体亚型：其它
荧光染料：其它
灵敏度 | 30 pg/mL |
| 检测范围 | 32.77-8000 pg/mL |
样本类型/体积 | 上清液 100 μL 血清 50 μL 血浆 50 μL |
操作时间 | 1 hr 20 min |
测试时间 | 4 hr 45 min |
Homogenous (no wash) | No |
| 批间变异系数（CV） | <12% |
| 批内变异系数（CV） | <10% |
仪器设备 | Colorimetric Microplate Reader 酶标仪 |
规格 | 96 Tests |
组份 | - 预包被96孔板 - 标准品 - 分析稀释浓缩液 - 生物素化检测抗体 -SAV-HRP - 洗涤液 - 显色剂 - 终止液 - 胶板盖 |
储存温度 | 2-8℃ |
| Protein name | KIM-1 |
| Protein aliases | CD365, HAVcr-1, Hepatitis A virus cellular receptor 1 homolog, Kidney injury molecule 1, KIM-1, T cell immunoglobulin and mucin domain-containing protein 1, T cell membrane protein 1, T-cell immunoglobulin and mucin domain containing 1, T-cell immunoglobulin mucin receptor 1, TIM-1, TIMD-1 |
物种（Tested） | 小鼠 |
试剂盒类型 | Sandwich ELISA Kit |
标记（染料） | HRP |
| 检测抗体偶联物 | Biotin |
| Gene aliases | AI503787, Havcr1, KIM-1, Kim1, TIM-1, Tim1, Timd1 |
| Gene ID | (Mouse) 171283 |
| Gene symbol | Havcr1 |
| UniProt ID | (Mouse) Q5QNS5 |
| The Mouse TIM-1 (HAVCR1) ELISA quantitates Ms TIM-1 in mouse serum, plasma, or cell culture medium. The assay will exclusively recognize both natural and recombinant Ms TIM-1.小鼠TIM-1（HAVCR1）ELISA定量检测小鼠血清，血浆或细胞培养基中的TIM-1。 该检测试剂盒将专门识别天然和重组Ms TIM-1。Principle of the method 方法原理The Mouse TIM-1 solid-phase sandwich ELISA (enzyme-linked immunosorbent assay) is designed to measure the amount of the target bound between a matched antibody pair. A target-specific antibody has been pre-coated in the wells of the supplied microplate. Samples, standards, or controls are then added into these wells and bind to the immobilized (capture) antibody. The sandwich is formed by the addition of the second (detector) antibody, a substrate solution is added that reacts with the enzyme-antibody-target complex to produce measurable signal. The intensity of this signal is directly proportional to the concentration of target present in the original specimen.小鼠TIM-1固相夹心ELISA（酶联免疫吸附测定）是测量匹配的抗体对之间结合的靶标量。 已在提供的微孔板的孔中预包被了靶标特异性抗体。 然后将样品，标准液或质控品添加到这些孔中，并与固定的（捕获）抗体结合。 通过添加第二（检测）抗体形成三明治，添加底物溶液，该底物溶液与酶-抗体-靶标复合物反应以产生可测量的信号。 该信号的强度与原始样品中存在的靶标浓度成正比。Rigorous validation 严格验证Each manufactured lot of this ELISA kit is quality tested for criteria such as sensitivity, specificity, precision, and lot-to-lot consistency. See manual for more information on validation.此ELISA试剂盒的每个制造批次均经过质量测试，其标准包括敏感性，特异性，精密度和批次间一致性。 有关验证的更多信息，请参见手册。Target information 靶标信息HAVCR1, a 359 A.A Class 1 integral membrane glycoprotein, is used by Hepatitis A virus to infect humans. It consists of a conserved N-terminal Cys-rich region, IgV (Immunoglobulin Variable region like) domain and a TSP-rich mucin domain in the extracellular region followed by a highly conserved tyrosine kinase phosphorylation motif in the cytoplasmic region. HAVCR1 is expressed on terminally differentiated CD4+ Th2 cells and regulates cytokine production. It plays an important role in the regulation of immune responses in the development of asthma and allergic responses. Its expression is critically upregulated in dedifferentiated kidney cells, thus indicating a possible role in regeneration of proximal tubule epithelium in Kidneys. HAVCR1 has shown to be upregulated in renal carcinomas, suggesting its role in tumor progression and metastasis.HAVCR1是一种359 A.A 1类整体膜糖蛋白，被甲型肝炎病毒用来感染人类。 它由细胞外区域中一个保守的N端富含Cys的区域，IgV（免疫球蛋白可变区）域和一个TSP丰富的粘蛋白域组成，随后在细胞质区域中具有一个高度保守的酪氨酸激酶磷酸化基序。 HAVCR1在最终分化的CD4 + Th2细胞上表达，并调节细胞因子的产生。 它在哮喘和过敏反应发展过程中的免疫反应调节中起重要作用。 它的表达在去分化的肾细胞中被严格上调，因此表明在肾脏近端小管上皮再生中可能发挥作用。 HAVCR1已显示在肾癌中上调，表明其在肿瘤进展和转移中的作用。For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.仅供研究使用。 不用于诊断过程。 未经明确授权不得转售。 |
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