CD8a Monoclonal Antibody (OKT8 (OKT-8)), FITC, eBioscience™
货号：11-0086-41 ,11-0086-42
规格：25 tests,100 tests
价格：835,1919
产品类型：流式抗体
品牌：eBioscience
抗原：CD8a
物种：人
宿主：小鼠
抗体亚型：IgG2a, kappa
克隆号：OKT8 (OKT-8)
荧光染料：FITC
| 抗体类型: | 流式抗体 | 同型对照： | Mouse IgG2a kappa Isotype Control (eBM2a), FITC, eBioscience |
| 浓度： | 5 µL/Test | 用法： | 5 µL (0.06 µg)/test (Flow） |
产品详细信息Description: The OKT8 monoclonal antibody reacts with the human CD8a molecule, an approximately 32-34 kDa cell surface receptor expressed either as a heterodimer with the CD8 beta chain (CD8 alpha beta) or as a homodimer (CD8 alphaalpha). A majority of thymocytes and a subpopulation of mature T cells and NK cells express CD8a. CD8 binds to MHC class I and through its association with protein tyrosine kinase p56lck plays a role in T-cell development and activation of mature T cells. Preliminary testing indicates that OKT8 and two other mouse anti-human CD8 antibodies (clone RPA-T8, Cat. No.14-0088 and clone HIT8a, Cat. No.14-0089) do not compete with each other for binding to human peripheral blood leukocytes by flow cytometric analysis, suggesting that they do not bind to similar epitopes or block each other by steric hindrance.Applications Reported: This OKT8 (OKT-8) antibody has been reported for use in flow cytometric analysis.Applications Tested: This OKT8 (OKT-8) antibody has been pre-titrated and tested by flow cytometric analysis of normal human peripheral blood cells. This can be used at 5 µL (0.06 µg) per test. A test is defined as the amount (µg) of antibody that will stain a cell sample in a final volume of 100 µL. Cell number should be determined empirically but can range from 10^5 to 10^8 cells/test.Excitation: 488 nm; Emission: 520 nm; Laser: Blue Laser.Filtration: 0.2 µm post-manufacturing filtered. 靶标信息CD8 molecule is composed of two chains termed alpha and beta. CD8 is found on a T cell subset of normal cytotoxic / suppressor cells which make up approximately 20 to 35% of human peripheral blood lymphocytes. The CD8 antigen is also detected on natural killer cells, 80% of thymocytes, on a subpopulation of 30% of peripheral blood null cells and 15 to 30% of bone marrow cells.
| 数据 |
| CD8a Antibody (11-0086-41) in Flow Staining of normal human peripheral blood cells with Mouse IgG2a kappa Isotype Control FITC (Product # 11-4724-42) (open histogram) or Anti-Human CD8a FITC (filled histogram). Cells in the lymphocyte gate were used for analysis.CD8a Antibody (11-0086-41)Vaccine 2008 -Published figure using CD8a monoclonal antibody (Product # 11-0086-41) |
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| 参考文献： |
| 1.Frontiers in pharmacology Disruption of PD-1 Enhanced the Anti-tumor Activity of Chimeric Antigen Receptor T Cells Against Hepatocellular Carcinoma.2.Scientific reports Extensive T cell cross-reactivity between diverse seasonal influenza strains in the ferret model.3.PloS one CCL20 Secretion from the Nucleus Pulposus Improves the Recruitment of CCR6-Expressing Th17 Cells to Degenerated IVD Tissues. |
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