CD66b Monoclonal Antibody (G10F5), FITC

货号：11-0666-41,11-0666-42

规格：25 Tests,25 Tests

价格：0,2096

产品类型：流式抗体

品牌：eBioscience

物种：人

宿主：小鼠

抗体亚型：IgM

克隆号：G10F5

荧光染料：FITC

类型:	单抗	同型对照：	Mouse IgM Isotype Control (11E10), FITC
浓度：	5 µL/Test	用法：	5 μL (0.5 μg)/test(Flow)

产品详细信息Description: This G10F5 monoclonal antibody reacts with human CD66b, one of four members of the CD66 family of granulocyte-specific activation antigens. Expressed on neutrophils and eosinophils, CD66b is upregulated following stimulation. This glycosyl-phosphatidylinositol-linked cell surface receptor plays a role in regulating neutrophil activation and adhesion to fibronectin, galectin-3, and E-selectin.Applications Reported: This G10F5 antibody has been reported for use in flow cytometric analysis.Applications Tested: This G10F5 antibody has been pre-titrated and tested by flow cytometric analysis of normal human peripheral blood cells. This can be used at 5 µL (0.5 µg) per test. A test is defined as the amount (µg) of antibody that will stain a cell sample in a final volume of 100 µL. Cell number should be determined empirically but can range from 10^5 to 10^8 cells/test.Excitation: 488 nm; Emission: 520 nm; Laser: Blue Laser.Filtration: 0.2 µm post-manufacturing filtered.靶标信息This gene encodes a member of the carcinoembryonic antigen (CEA) gene family, which belongs to the immunoglobulin superfamily. Two subgroups of the CEA family, the CEA cell adhesion molecules and the pregnancy-specific glycoproteins, are located within a 1.2 Mb cluster on the long arm of chromosome 19. Eleven pseudogenes of the CEA cell adhesion molecule subgroup are also found in the cluster. The encoded protein was originally described in bile ducts of liver as biliary glycoprotein. Subsequently, it was found to be a cell-cell adhesion molecule detected on leukocytes, epithelia, and endothelia. The encoded protein mediates cell adhesion via homophilic as well as heterophilic binding to other proteins of the subgroup. Multiple cellular activities have been attributed to the encoded protein, including roles in the differentiation and arrangement of tissue three-dimensional structure, angiogenesis, apoptosis, tumor suppression, metastasis, and the modulation of innate and adaptive immune responses. Multiple transcript variants encoding different isoforms have been reported, but the full-length nature of all variants has not been defined.

数据

CD66b Antibody (11-0666-41) in FlowStaining of normal human peripheral blood cells with Mouse IgM Isotype Control PE (Product # 11-4754) (blue histogram) or Anti-Human CD66b PE (purple histogram). Cells in the lymphocyte (left) and granulocyte (right) gates were used for analysis.

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参考文献：

1.Mediators of inflammationNeuropeptides SP and CGRP Diminish theMoraxella catarrhalisOuter Membrane Vesicle- (OMV-) Triggered Inflammatory Response of Human A549 Epithelial Cells and Neutrophils."11-0666 was used in Flow cytometry/Cell sorting to suggest that SP and CGRP mediate the dampening of proinflammatory action triggered by M. catarrhalis OMVs towards cells engaged in lung inflammation in vitro."AuthorsAugustyniak D,Roszkowiak J,Wiśniewska I,Skała J,Gorczyca D,Drulis-Kawa Z2.PLoS neglected tropical diseasesPathological manifestations in lymphatic filariasis correlate with lack of inhibitory properties of IgG4 antibodies on IgE-activated granulocytes."11-0666 was used in Flow cytometry/Cell sorting to suggest that alterations in IgG4 antibodies are associated with the different clinical phenotypes in lymphatic filariasis endemic regions."AuthorsProdjinotho UF,von Horn C,Debrah AY,Batsa Debrah L,Albers A,Layland LE,Hoerauf A,Adjobimey T

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