Rat P-Cadherin ELISA Kit/大鼠P-钙黏着蛋白ELISA试剂盒
货号：ERA48RB,ERA48RBX5
规格：96 Tests,5X96 Tests
价格：6641,29884
产品类型：Platinum ELISA
品牌：Thermo Fisher
物种：大鼠
宿主：其它
抗体亚型：其它
荧光染料：其它
灵敏度 | 0.041 ng/mL |
| 检测范围 | 0.041-10 ng/mL |
样本类型/体积 | 血清 50 μL 血浆 50 μL 上清液 50 μL |
操作时间 | 1 hr 20 min |
测试时间 | 4 hr 45 min |
Homogenous (no wash) | No |
| 批间变异系数（CV） | <12% |
| 批内变异系数（CV） | <10% |
仪器设备 | Colorimetric Microplate Reader 酶标仪 |
规格 | 5 x 96 Tests |
组份 | - 预包被96孔板 - 标准品 - 测定稀释浓缩液 - 生物素化检测抗体 - SAV-HRP - 洗涤液 - 显色剂 - 终止液 - 胶板盖 |
储存温度 | 2-8℃ |
| Protein name | P-cadherin |
| Protein aliases | cadherin 3, type 1, P-cadherin (placental), cadherin-3 |
物种（Tested） | 大鼠 |
试剂盒类型 | Sandwich ELISA Kit |
标记（染料） | HRP |
| 检测抗体偶联物 | Biotin |
| Gene ID | (Rat) 116777 |
| Gene symbol | Cdh3 |
| Rat P-Cadherin quantitates rat P-Cadherin in serum, plasma, supernatant. The assay will exclusively recognize both natural and recombinant rat P-Cadherin.大鼠P-钙黏着蛋白定量测定血清，血浆，上清液中的大鼠P-钙黏着蛋白。该检测试剂盒将专门识别天然和重组大鼠P-钙黏着蛋白。Target information 靶标信息P-cadherin, also known as Cadherin-3, is a Type 1 cadherin protein that belongs to the cadherin superfamily. Type 1 cadherins are single-pass transmembrane proteins that have 5 extracellular cadherin repeats and an intracellular domain that binds p120-catenin and beta-catenin. Cadherins are calcium-dependent cell-cell adhesion glycoproteins responsible for a range of processes including development, wound healing, cell-cell signaling, cell growth and differentiation. P-cadherin is expressed in human fetal structures, and in adult tissues such as the basal layer of the epidermis, breast, prostate, ovary, cervix, hair follicle, and corneal endothelium. P-cadherin expression has also been reported on embryonic stem cells, and stem cells of the normal mammary gland, and hair follicle. Overexpression of P-cadherin has been associated with poor prognosis in breast, prostate, ovary, colon, and stomach carcinomas. Mutations in CDH3 are associated with congential hypotrichosis with juvenile macular dystrophy.P-钙粘着蛋白，也称为Cadherin-3，是一种1型钙粘着蛋白，属于钙粘着蛋白超家族。 1型钙粘蛋白是具有5个细胞外钙粘蛋白重复序列和结合p120-catenin和β-catenin的细胞内结构域的单程跨膜蛋白。钙黏着蛋白是钙依赖性细胞-细胞粘附糖蛋白，负责一系列过程，包括发育，伤口愈合，细胞信号传导，细胞生长和分化。 P-钙黏着蛋白在人的胎儿结构和成人组织中，例如表皮的基底层，乳房，前列腺，卵巢，子宫颈，毛囊和角膜内皮中表达。在胚胎干细胞，正常乳腺的干细胞和毛囊上也有过P-钙粘着蛋白表达的报道。 P-钙黏着蛋白的过表达与乳腺癌，前列腺癌，卵巢癌，结肠癌和胃癌的不良预后有关。 CDH3突变与少年性黄斑营养不良伴持续性睾丸下垂症有关。For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.仅供研究使用。 不用于诊断过程。 未经明确授权不得转售。 |
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