IL-2 Monoclonal Antibody (AB12-3G4), Functional Grade, eBioscience™/IL-2 单克隆 (AB12-3G4), 功能抗体, eBioscience™

货号：16-7027-85,16-7027-38,16-7027-025,16-7027-050

规格：500 µg,5 mg,25 mg,50 mg

价格：3496,19872,72266,120443

产品类型：流式抗体

品牌：eBioscience

抗原：IL-2

物种：人

宿主：小鼠

抗体亚型：IgG2a, kappa

克隆号：AB12-3G4

荧光染料：其它

_ueditor_page_break_tag_

类型:	一抗(功能抗体）	同型对照：	Mouse IgG2a kappa Isotype Control (eBM2a), Functional Grade, eBioscience™
浓度：	1 mg/mL	用法：	Assay-Dependent（中和实验）；Assay-Dependent（功能检测）

产品详细信息Description: This AB12-3G4 monoclonal antibody reacts with and inhibits the bioactivity of human IL-2. IL-2 is a 15 kDa cytokine expressed by B cells, T cells, and dendritic cells. IL-2 signals via a heterotrimeric receptor (CD25) and results in the activation of Jak/STAT pathways. IL-2 plays a critical role in the proliferation, activation, and differentiation of T cells. The development of CD4+CD25+ regulatory T cells is especially dependent on the presence of IL-2, making it an important immunoregulatory cytokine.Applications Reported: This AB12-3G4 monoclonal antibody inhibits the bioactivity of human IL-2.Applications Tested: The ND50 of AB12-3G4, as determined by the neutralization of Human IL-2-induced proliferation of the CTLL-2 cell line, is less than or equal to 60 ng/mL in the presence of 10 ng/mL Human IL-2 Recombinant Protein. The neutralization dose of this antibody will vary depending on cell type, assay method, and cytokine concentration.Storage and handling: Use in a sterile environment.Filtration: 0.2 µm post-manufacturing filtered.Purity: Greater than 90%, as determined by SDS-PAGE.Endotoxin Level: Less than 0.001 ng/µg antibody, as determined by LAL assay.Aggregation: Less than 10%, as determined by HPLC.靶标信息Interleukin 2 (IL-2) is an immuno-modulatory cytokine that is important for the proliferation of activated T cells, differentiation of B cells, natural killer cells, monocytes and macrophages. IL-2 signals through the IL-2 receptor (IL-2R), a heterotrimeric protein complex whose gamma chain is also shared by interleukin 4 (IL-4) and interleukin 7 (IL-7). The expression of the IL-2 gene in mature thymocytes is monoallelic, which represents an unusual regulatory mode for controlling the precise expression of a single gene. The targeted disruption of a gene similar to IL-2 in mice leads to an ulcerative colitis-like disease that suggests an essential role of this gene in the immune response to antigenic stimuli.仅用于科研。不用于诊断过程。

推荐产品：

二抗荧光二抗免疫组化一抗标签抗体

参考文献：

功能检测1.JCI insightBlocking MHC class II on human endothelium mitigates acute rejection."16-7027 was used in an ELISA assay to establish the immune cell network involved in acute allograft rejection in humans and identify targets for minimising this rejection."AuthorsAbrahimi P,Qin L,Chang WG,Bothwell AL,Tellides G,Saltzman WM,Pober JS

技术参数

© Bio-Rad伯乐代理官网-伯乐抗体-伯乐层析Aminex色谱柱是专业的授权总代理区域代理经销平台。
© 如需询价，请加客服QQ：1749072012 、客服微信：jinshanbio，或发送邮件到1749072012@qq.com
© 平台为生命科学研究相关领域提供一站式耗材试剂仪器解决方案和采购服务，数据资源基于CC协议。
© 本文地址：https://biorod.cn/thread-26403.htm