IL-6 Monoclonal Antibody (MQ2-13A5), Functional Grade, eBioscience™/IL-6 单克隆 (MQ2-13A5), 功能抗体, eBioscience™

货号：16-7069-81,16-7069-85,16-7069-38,16-7069-025,16-7069-050

规格：50 µg,500 µg,5 mg,25 mg,50 mg

价格：1156,3386,19872,72266,120443

产品类型：流式抗体

品牌：eBioscience

抗原：IL-6

物种：人/小鼠

宿主：大鼠

抗体亚型：IgG1, kappa

克隆号：MQ2-13A5

荧光染料：其它

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类型:	一抗(功能抗体）	同型对照：	Rat IgG1 kappa Isotype Control (eBRG1), Functional Grade, eBioscience™
浓度：	1 mg/mL	用法：	Assay-Dependent（中和实验）；Assay-Dependent（ELISA）

产品详细信息Description: The MQ2-13A5 antibody reacts with human interleukin-6 (IL-6), a 21-28 kDa cytokine secreted by a variety of cell types.Applications Reported: This MQ2-13A5 antibody has been reported for use in cytokine neutralization, ELISPOT, and ELISA capture.Applications Tested: The MQ2-13A5 antibody has been tested for neutralizing IL-6 binding and biological activity.Storage and handling: Use in a sterile environment.Filtration: 0.2 µm post-manufacturing filtered.Purity: Greater than 90%, as determined by SDS-PAGE.Endotoxin Level: Less than 0.001 ng/µg antibody, as determined by LAL assay.Aggregation: Less than 10%, as determined by HPLC.靶标信息Interleukin 6 (IL-6) is a multifunctional 26 kD protein originally discovered in the medium of RNA-stimulated fibroblastoid cells. IL-6 appears to be directly involved in the responses that occur after infection and cellular injury, and it may prove to be important as IL-1 and TNF-a in regulating the acute phase response. IL-6 is reported to be produced by fibroblasts, activated T cells, activated monocytes or macrophages and endothelial cells. IL-6 acts upon a variety of cells including myeloidprogenitor cells, T cells, B cells, and hepatocytes. In addition, IL-6 appears to interact with IL-2 in the proliferation of T lymphocytes. IL-6 potentiates the proliferative effect of IL-3 on multipotential hematopoietic progenitors. IL-6 plays a critical role in B-cell differentiation to plasma cells and is a potent growth factor for plasmacytoma and myeloma. IL-6 is a very useful culture supplement for the generation of a high number of antibody-producing hybridomas. Primarily produced at sites of acute and chronic inflammation, IL-6 is secreted into the serum and induces a transcriptional inflammatory response through interleukin 6 receptor, alpha. The functioning of IL-6 is implicated in a wide variety of inflammation-associated disease states including diabetes mellitus and systemic juvenile rheumatoid arthritis.仅用于科研。不用于诊断过程。未经明确授权不得转售。

数据

IL-6 Antibody (16-7069-81)Stem cells (Dayton, Ohio) 2017 -Published figure using IL-6 monoclonal antibody (Product # 16-7069-81)

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参考文献：

流式1.Proceedings of the National Academy of Sciences of the United States of AmericaBiallelic hypomorphic mutations in a linear deubiquitinase define otulipenia, an early-onset autoinflammatory disease."Published figure using IL-6 monoclonal antibody (Product # 16-7069-81) in ELISA"2.PloS oneTL1A induces TCR independent IL-6 and TNF-α production and growth of PLZF⁺ leukocytes."Published figure using IL-6 monoclonal antibody (Product # 16-7069-81) in Flow Cytometry"功能检测3.Cell death and diseaseDecitabine, a DNA-demethylating agent, promotes differentiation via NOTCH1 signaling and alters immune-related pathways in muscle-invasive bladder cancer."16-7069 was used in Functional assays to show that non-cytotoxic nanomolar decitabine concentrations modify the bladder cancer transcriptome to activate NOTCH1 at the mRNA and protein level, increase double-stranded RNA sensors and CK5-dependent differentiation."ELISA4.Proceedings of the National Academy of Sciences of the United States of AmericaBiallelic hypomorphic mutations in a linear deubiquitinase define otulipenia, an early-onset autoinflammatory disease."Published figure using IL-6 monoclonal antibody (Product # 16-7069-81) in ELISA"IHC5.Stem cells (Dayton, Ohio)Mesenchymal Stromal Cell-Derived Interleukin-6 Promotes Epithelial-Mesenchymal Transition and Acquisition of Epithelial Stem-Like Cell Properties in Ameloblastoma Epithelial Cells."16-7069 was used in Immunohistochemistry-immunofluorescence to isolate and characterise mesenchymal stromal cells (AM-MSC) and epithelial cells from follicular ameloblastoma, and demonstrate that in vitro AM-MSCs secrete higher levels of IL-6 as compared to epithelial cells."

技术参数

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