CD122 Monoclonal Antibody (TM-b1 (TM-beta1)), Functional Grade, eBioscience™/CD122 单克隆 (TM-b1 (TM-beta1)), 功能抗体, eBioscience™

货号：16-1222-82,16-1222-81,16-1222-85,16-1222-38,16-1222-025,16-1222-050

规格：100 µg,50 µg,500 µg,5 mg,25 mg,50 mg

价格：1865,1283,3496,24089,72266,120443

产品类型：流式抗体

品牌：eBioscience

抗原：CD122

物种：小鼠

宿主：大鼠

抗体亚型：IgG2b, kappa

克隆号：TM-b1 (TM-beta1)

荧光染料：其它

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类型:	一抗(功能抗体）	同型对照：	Rat IgG2b kappa Isotype Control (eB149/10H5), Functional Grade, eBioscience™
浓度：	1 mg/mL	用法：	0.5 µg/test（Flow）;Assay-Dependent（中和）;Assay-Dependent（功能检测）

产品详细信息Description: The TM-b1 monoclonal antibody reacts with mouse CD122, the 90-110 kDa interleukin-2 receptor beta chain (IL-2R beta). CD122 is expressed by NK cells and some T cells in the periphery, and is upregulated by activation. CD122 associates with CD25 and CD132 (common gamma chain) to form the high affinity IL-2 receptor. High affinity binding of IL-2 to the IL-2 receptor is inhibited by the TM-b1 antibody.Applications Reported: This TM-b1 (TM-beta1) antibody has been reported foruse in flow cytometric analysis. It has also been reported to block high affinity binding of IL-2 to its receptor.Applications Tested: The TM-b1 (TM-beta1) antibody has been tested by flow cytometric analysis of mouse splenocytes. This can be used at less than or equal to 0.5 µg per test. A test is defined as the amount (µg) of antibody that will stain a cell sample in a final volume of 100 µL. Cell number should be determined empirically but can range from 10^5 to 10^8 cells/test. It is recommended that the antibody be carefully titrated for optimal performance in the assay of interest.Storage and handling: Use in a sterile environment.Filtration: 0.2 µm post-manufacturing filtered.Purity: Greater than 90%, as determined by SDS-PAGE.Endotoxin Level: Less than 0.001 ng/µg antibody, as determined by LAL assay.Aggregation: Less than 10%, as determined by HPLC.靶标信息CD122 (Interleukin 2 receptor) is involved in T cell-mediated immune responses, primarily expressed in the hematopoietic system and is present in 3 forms. The low affinity form of CD122 is a monomer of the alpha subunit and is not involved in signal transduction. The intermediate affinity form consists of an alpha/beta subunit heterodimer, while the high affinity form consists of an alpha/beta/gamma subunit heterotrimer. Both the intermediate and high affinity forms of the receptor are involvedin receptor-mediated endocytosis and transduction of mitogenic signals from CD122. The protein encoded by the CD122 gene represents the beta subunit and is a type I membrane protein. Diseases associate with CD122 protein dysfunction include oligoarticular juvenile idiopathic arthritis and rheumatoid factor negative juvenile idiopathic arthritis.仅用于科研。不用于诊断过程。

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参考文献：

流式1.Nature immunologyCostimulation via the tumor-necrosis factor receptor superfamily couples TCR signal strength to the thymic differentiation of regulatory T cells."16-1222 was used in Flow cytometry/Cell sorting to study the role of TNF receptors in the thymic development of Treg cells.."AuthorsMahmud SA,Manlove LS,Schmitz HM,Xing Y,Wang Y,Owen DL,Schenkel JM,Boomer JS,Green JM,Yagita H,Chi H,Hogquist KA,Farrar MA2.The Journal of clinical investigationTAP-independent self-peptides enhance T cell recognition of immune-escaped tumors."16-1222 was used in Flow cytometry/Cell sorting to analyse thymus selection and peripheral behaviour of T cells with specificity for the self-antigen known as T cell epitopes associated with impaired peptide processing (TEIPP)."AuthorsDoorduijn EM,Sluijter M,Querido BJ,Oliveira CC,Achour A,Ossendorp F,van der Burg SH,van Hall T3.Skeletal muscleSkeletal muscle interleukin 15 promotes CD8(+) T-cell function and autoimmune myositis."16-1222 was used in Flow cytometry/Cell sorting to highlight a new level of complexity in TRAIL signalling and point to an improved therapeutic rationale in view of hitherto disappointing results."AuthorsHuang PL,Hou MS,Wang SW,Chang CL,Liou YH,Liao NS

技术参数

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