IFNAR1 Monoclonal Antibody (MAR1-5A3), Functional Grade, eBioscience™/IFNAR1 单克隆 (MAR1-5A3), 功能抗体, eBioscience™

货号：16-5945-85,16-5945-38,16-5945-025

规格：500 µg,5 mg,25 mg

价格：5439,24192,74795

产品类型：流式抗体

品牌：eBioscience

抗原：IFNAR1

物种：小鼠

宿主：小鼠

抗体亚型：IgG1, kappa

克隆号：MAR1-5A3

荧光染料：其它

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类型:	一抗(功能抗体）	同型对照：	IgG1 kappa
浓度：	1 mg/mL	用法：	Assay-Dependent（Neu）；Assay-Dependent（FN）

产品详细信息Description: The MAR1-5A3 monoclonal antibody reacts with mouse IFN alpha/beta receptor subunit 1 (IFNAR-1). The type I IFN receptor subunit 1 is co-expressed with IFNAR-2 on nearly all cells and make up the heterodimeric receptor complex that binds to all type I IFNs, IFN alpha and IFN beta. Type I IFNs are a group of structurally and functionally related proteins that demonstrate antiviral, antiparasitic, and antiproliferative activities.Applications Reported: The MAR1-5A3 antibody has been reported for use in neutralization of IFNAR1 bioactivity.Applications Tested: The Functional Grade Purified MAR1-5A3 antibody has been tested by LAL assay to verify low endotoxin levels, by bioassay for neutralization of mouse IFNAR-1bioactivity. The MAR1-5A3 antibody at 0.04 µg/mL has been found to inhibit by 50% the biological effects of 0.5 ng/mL mouse IFN-a2 (ND50), in an EMCV assay of L929 cell protection. Detailed information and protocols about cytokine bioassays and in vitro cytokine neutralization using antibodies can be found in Best Protocols® section.Storage and handling: Use in a sterile environment.Filtration: 0.2 µm post-manufacturing filtered.Purity: Greater than 90%, as determined by SDS-PAGE.Endotoxin Level: Less than 0.001 ng/µg antibody, as determined by LAL assay.Aggregation: Less than 10%, as determined by HPLC.靶标信息Interferons are widely used therapeutic agents because of their anti tumor and antiviral effects and because of their modulatory effects on the immune system (Biron,2001, Kirkwood, 2002). These cytokines produce their effects by binding to the Type 1 Interferon- and Receptor (IFNAR1). Down regulation of this receptor plays a key role in determining the magnitude and duration of cytokine signaling. This down regulation is thought to be influenced by phosphorylation of Serine 535 and 539 in the IFNAR1 (Kumar et al., 2003).仅用于科研。不用于诊断过程。

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参考文献：

流式1.Proceedings of the National Academy of Sciences of the United States of AmericaC-type lectin receptor DCIR modulates immunity to tuberculosis by sustaining type I interferon signaling in dendritic cells."16-5945 was used in Flow cytometry/Cell sorting to reveal the modulatory role of the C-type lectin, DCIR, in tuberculosis-associated inflammation."AuthorsTroegeler A,Mercier I,Cougoule C,Pietretti D,Colom A,Duval C,Vu Manh TP,Capilla F,Poincloux R,Pingris K,Nigou J,Rademann J,Dalod M,Verreck FA,Al Saati T,Lugo-Villarino G,Lepenies B,Hudrisier D,Neyrolles OELISA2.Journal of immunology (Baltimore, Md. : 1950)TLR and RLR Signaling Are Reprogrammed in Opposite Directions after Detection of Viral Infection."16-5945 was used in an ELISA assay to demonstrate that innate recognition of viral infection critically modifies responses to pattern-recognition receptor stimulation."AuthorsHotz C,Roetzer LC,Huber T,Sailer A,Oberson A,Treinies M,Heidegger S,Herbst T,Endres S,Bourquin C中和3.Journal of immunology (Baltimore, Md. : 1950)SARM regulates CCL5 production in macrophages by promoting the recruitment of transcription factors and RNA polymerase II to the Ccl5 promoter."16-5945 was used in Neutralization experiments to characterise TLR-induced cytokine responses in murine macrophages deficient in the Toll/IL-1R adaptor sterile α and HEAT/Armadillo motif-containing protein (SARM)."AuthorsGürtler C,Carty M,Kearney J,Schattgen SA,Ding A,Fitzgerald KA,Bowie AG4.Journal of neuroinflammationFast type I interferon response protects astrocytes from flavivirus infection and virus-induced cytopathic effects."16-5945 was used in Blocking experiments to show that astrocytes control viral replication of different TBEV strains, JEV, WNV, and ZIKV. In contrast to fibroblast, astrocytes mount a rapid interferon response and restrict viral spread."AuthorsLindqvist R,Mundt F,Gilthorpe JD,Wölfel S,Gekara NO,Kröger A,Överby AK功能检测5.Journal of neuroinflammationCell-type- and region-specific restriction of neurotropic flavivirus infection by viperin."16-5945 was used in Functional assays to show that viperin restricts replication of neurotropic flaviviruses in the central nervous system in a region- and cell-type-specific manner."AuthorsLindqvist R,Kurhade C,Gilthorpe JD,Överby AK6.Proceedings of the National Academy of Sciences of the United States of AmericaC-type lectin receptor DCIR modulates immunity to tuberculosis by sustaining type I interferon signaling in dendritic cells."16-5945 was used in Flow cytometry/Cell sorting to reveal the modulatory role of the C-type lectin, DCIR, in tuberculosis-associated inflammation."AuthorsTroegeler A,Mercier I,Cougoule C,Pietretti D,Colom A,Duval C,Vu Manh TP,Capilla F,Poincloux R,Pingris K,Nigou J,Rademann J,Dalod M,Verreck FA,Al Saati T,Lugo-Villarino G,Lepenies B,Hudrisier D,Neyrolles O

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