| Description: Description: This AMC908 monoclonal antibody reacts with the human CD8a molecule, an approximately 32-34 kDa cell surface receptor expressed either as a heterodimer with the CD8 beta chain (CD8 alpha beta) or as a homodimer (CD8 alphaalpha). A majority of thymocytes and a subpopulation of mature T cells and NK cells express CD8a. CD8 binds to MHC class I and through its association with protein tyrosine kinase p56lck plays a role in T-cell development and activation of mature T cells.Applications Reported: This AMC908 antibody has been reported for use in immunohistochemical staining of formalin-fixed paraffin embedded tissue sections.Applications Tested: This AMC908 antibody has been tested by immunohistochemistry on formalin-fixed paraffin embedded human tissue using low pH antigen retrieval and can be used at less than or equal to 5 µg/mL. It is recommended that the antibody be carefully titrated for optimal performance in the assay of interest.Excitation: 488 nm; Emission: 519 nm; Laser: Blue Laser.Filtration: 0.2 µm post-manufacturing filtered.Target Information CD8 molecule is composed of two chains termed alpha and beta. CD8 is found on a T cell subset of normal cytotoxic / suppressor cells which make up approximately 20 to 35% of human peripheral blood lymphocytes. The CD8 antigen is also detected on natural killer cells, 80% of thymocytes, on a subpopulation of 30% of peripheral blood null cells and 15 to 30% of bone marrow cells. For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization. |
| 1.Oncoimmunology Long-lived pancreatic ductal adenocarcinoma slice cultures enable precise study of the immune microenvironment. "53-0008 was used in Immunohistochemistry-immunofluorescence to demonstrate the potential of using tumour slice cultures to study the immune microenvironment of pancreatic ductal adenocarcinoma." AuthorsJiang X,Seo YD,Chang JH,Coveler A,Nigjeh EN,Pan S,Jalikis F,Yeung RS,Crispe IN,Pillarisetty VG A deletion in the gene encoding the CD45 antigen in a patient with SCID.2001Authors Tchilian EZ,Wallace DL,Wells RS,Flower DR,Morgan G,Beverley PC2.OncoimmunologyLong-lived pancreatic ductal adenocarcinoma slice cultures enable precise study of the immune microenvironment. "53-0008 was used in Immunohistochemistry-immunofluorescence to demonstrate the potential of using tumour slice cultures to study the immune microenvironment of pancreatic ductal adenocarcinoma." AuthorsJiang X,Seo YD,Chang JH,Coveler A,Nigjeh EN,Pan S,Jalikis F,Yeung RS,Crispe IN,Pillarisetty VG |
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