CD25 Monoclonal Antibody (GLLZDMY), eBioscience™

货号：14-0256-80,14-0256-82

规格：25 µg,100 µg

价格：830,2113

产品类型：免疫组化一抗

品牌：eBioscience

抗原：CD25

物种：人

宿主：小鼠

抗体亚型：IgG1, kappa

克隆号：GLLZDMY

荧光染料：其它

类型:	一抗	同型对照：	IgG1, kappa
浓度：	0.5 mg/mL	用法：	5 µg/mL(IHC (P))

产品详细信息Description: This GLLZDMY monoclonal antibody reacts with human CD25, which is also known as the low-affinity interleukin (IL)-2 receptor alpha. CD25 is expressed on activated T cells (including a subset of regulatory T cells), B cells, and macrophages. This receptor subunit associates with CD122, the IL-2 receptor beta chain, and CD132, the common gamma chain, to form the high-affinity IL-2 receptor. IL-2 receptor signaling has been linked to cell proliferation and survival in lymphocytes. CD25is a marker for Hodgkin's disease, and has been associated with such autoimmune diseases such as Type I diabetes.Applications Reported: This GLLZDMY antibody has been reported for use in western blotting, and immunohistochemical staining of formalin-fixed paraffin embedded tissue sections.Applications Tested: This GLLZDMY antibody has been tested by immunohistochemistry of formalin-fixed paraffin embedded tissue using either low or high pH antigen retreival and can be used at 5 µg/mL. It is recommended that the antibody be carefully titrated for opitmal performance in the assay of interest.Purity: Greater than 90%, as determined by SDS-PAGE.Aggregation: Less than 10%, as determined by HPLC.Filtration: 0.2 µm post-manufacturing filtered.靶标信息CD25 (IL2 receptor alpha chain/IL2RA) is a cytokine that plays a role in the proliferation of T and B lymphocytes. The receptor of this cytokine (IL2RA) is a heterotrimeric protein complex with a gamma chain also shared by interleukin 4 (IL4) and interleukin 7 (IL7). IL2RA, IL2R beta chain (IL2RB), and the IL2R gamma chain (IL2RG), constitute the high-affinity IL2 receptor. Homodimeric IL2RA chains result in low-affinity receptor, while homodimeric IL2RB chains produce a medium-affinity receptor. The expression of IL2 in mature thymocytes is monoallelic, which represents an unusual regulatory mode for controlling the precise expression of a single gene. IL2 is primarily produced by mature T cells. IL2 plays an important role as a growth factor, differentiation factor, and regulator of cell death. IL-2 stimulates the proliferation of B cells, augments natural killer cell activity, and inhibits granulocyte macrophage colony formation. The targeted disruption of a similar gene in mice leads to ulcerative colitis-like disease, which suggests a role in the immune response to antigenic stimuli. Mutations in this gene are associated with interleukin 2 receptor alpha deficiency.仅用于科研。不用于诊断过程。

数据

CD25 Antibody (14-0256-80) in IHC (P)Immunohistochemistry of formalin-fixed paraffin embedded human tonsil using 5 µg/mL of Anti-Human CD25 Purified, followed by Anti-Mouse IgG Biotin, Streptavidin HRP and DAB visualization. Nuclei are counterstained with hematoxylin.

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