Rat anti Mouse CD11b antibody, clone 5C6
货号：MCA711GT,MCA711G,MCA711
规格：25 µg,0.25 mg,0.1 mg
价格：825,3043,5100
产品类型：流式抗体
品牌：Bio-Rad
抗原：CD11b
物种：小鼠
宿主：大鼠
抗体亚型：IgG2b
克隆号：5C6
荧光染料：Purified
| 产品介绍 | | |
| Rat anti Mouse CD11b antibody, clone 5C6recognizes CD11b, also known as the integrin alpha M chain. CD11b is implicated in various adhesive interactions of monocytes, macrophages and granulocytes as well as in mediating the uptake of complement-coated particles.Rat anti Mouse CD11b antibody, clone 5C6 immunoprecipitates a heterodimer of ~165 and ~95 kDa. This clone also exhibits various functional properties, reportedly inhibiting adhesionin vitroand inflammatory recruitmentin vivo. Rat anti Mouse CD11b antibody, clone 5C6 also inhibits delayed hypersensitivity, potentiates bacterial infections and inhibits type 1 diabetes. |
| 产品详情 | | |
| Target Species | Mouse |
| Product Form | Purified IgG - liquid |
| Preparation | - MCA711: Purified IgG prepared by affinity chromatography on Protein G from tissue culture supernatant
- MCA711G, MCA711GT: Purified IgG prepared by ion exchange chromatography
|
| Buffer Solution | Phosphate buffered saline |
| Immunogen | Thioglycollate-elicited peritoneal macrophages (TPM) |
| Preservative Stabilisers | 0.09%Sodium Azide |
| Carrier Free | Yes |
| Approx. Protein Concentrations | IgG concentration 1.0 mg/ml |
| Fusion Partners | Spleen cells from AO rats were fused with cells of the Y3 rat myeloma cell line |
| Regulatory | For research purposes only |
| Guarantee | 12 months from date of despatch |
| 存储条件 | | |
| This product is shipped at ambient temperature. It is recommended to aliquot and store at -20°C on receipt. When thawed, aliquot the sample as needed. Keep aliquots at 2-8°C for short term use (up to 4 weeks) and store the remaining aliquots at -20°C.Avoid repeated freezing and thawing as this may denature the antibody. Storage in frost-free freezers is not recommended. |
| 应用 | | |
| Application Name | Verified | Min Dilution | Max Dilution |
| Flow Cytometry | √ | | |
| This product has been reported to work in the following applications. This information is derived from testing within our laboratories, peer-reviewed publications or personal communications from the originators. Please refer to references indicated for further information. For general protocol recommendations, please visit theantibody protocolspage.Where this antibody has not been tested for use in a particular technique this does not necessarily exclude its use in such procedures. Suggested working dilutions are given as a guide only. It is recommended that the user titrates the antibody for use in their own system using appropriate negative/positive controls. |
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| 文献 |
| 1.Dohi, K.et al.(2010) Gp91phox (NOX2) in classically activated microglia exacerbates traumatic brain injury.J Neuroinflammation. 7: 41.2.Engwerda, C.R.et al.(2002) Locally up-regulated lymphotoxin alpha, not systemic tumor necrosis factor alpha, is the principle mediator of murine cerebral malaria.J Exp Med. 195: 1371-7.3.Heneka, M.T.et al.(2010) Locus ceruleus controls Alzheimer's disease pathology by modulating microglial functions through norepinephrine.Proc Natl Acad Sci U S A. 107: 6058-63.4.Kim, D.et al.(2010) NADPH oxidase 2-derived reactive oxygen species in spinal cord microglia contribute to peripheral nerve injury-induced neuropathic pain.Proc Natl Acad Sci U S A. 107: 14851-6. |
技术参数 产品应用 Flow
产品类型 Monoclonal Antibody
推荐用于 Flow
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