| 产品介绍 | | |
| Rabbit anti Human VEGF receptor 2 antibodydetects vascular endothelial growth factor receptor 2 (VEGFR2), a member of the tyrosine kinase family that plays an essential role in transducing the major signals for angiogenesis. VEGFR2 has also been implicated in embryonic development, wound healing, cell proliferation, migration and differentiation.VEGFR2 is expressed mostly on vascular endothelial cells, and is expressed on a subpopulation of haematopoietic cells which might be the progenitor for endothelial cells.Mutated forms of VEGFR2 have been implicated in cancer and diabetic retinopathy, where it results in pathological angiogenesis. |
| 产品详情 | | |
Target Species | Human |
Product Form | Purified IgG - liquid |
Antiserum Preparation | Antisera to human VEGF receptor 2 were raised by repeated immunisations of rabbits with highly purified antigen. Purified IgG prepared by affinity chromatography. |
Buffer Solution | Phosphate buffered saline |
Preservative Stabilisers | 0.1%Sodium Azide (NaN3) |
Approx. Protein Concentrations | IgG concentration 0.5 mg/ml |
Immunogen | Synthetic peptide corresponding to an internal domain of human VEGF receptor 2, conjugated to Keyhole Limpet Hemocyanin (KLH). |
Regulatory | For research purposes only |
Guarantee | 12 months from date of despatch |
| 存储条件 | | |
| This product is shipped at ambient temperature. It is recommended to aliquot and store at -20°C on receipt. When thawed, aliquot the sample as needed. Keep aliquots at 2-8°C for short term use (up to 4 weeks) and store the remaining aliquots at -20°C.Avoid repeated freezing and thawing as this may denature the antibody. Storage in frost-free freezers is not recommended. |
| 应用 | | |
Application Name | Verified | Min Dilution | Max Dilution |
Immunohistology - Paraffin1 | √ | | 10ug/ml |
This product has been reported to work in the following applications. This information is derived from testing within our laboratories, peer-reviewed publications or personal communications from the originators. Please refer to references indicated for further information. For general protocol recommendations, please visit theantibody protocolspage.1This product requires antigen retrieval using heat treatment prior to staining of paraffin sections.Sodium citrate buffer pH 6.0 is recommended for this purpose.Where this product has not been tested for use in a particular technique this does not necessarily exclude its use in such procedures. Suggested working dilutions are given as a guide only. It is recommended that the user titrates the product for use in their own system using appropriate negative/positive controls.- Histology Positive Control Tissue
- Breast carcinoma.
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| 数据 |
| Staining of human breast carcinoma with Rabbit anti Human VEGF Receptor 2 (AHP1327) |
| 文献 |
| 1. Shibuya, M. (2006) Differential roles of vascular endothelial growth factor receptor-1 and receptor-2 in angiogenesis.J Biochem Mol Biol. 39 (5): 469-78.2. Hjelmgren, O.et al.(2016) Increased Vascularization in the Vulnerable Upstream Regions of Both Early and Advanced Human Carotid Atherosclerosis.PLoS One. 11 (12): e0166918. |
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