Applications

FA

Synonyms:

IWR-1-endo, IWR-1, IWR1-endo

Formulation:

Crystalline solid

Chemical Name:

4-[(3aR,4S,7R,7aS)-1,3,3a,4,7,7a-hexahydro-1,3-dioxo-4,7-methano-2H-isoindol-2-yl]-N-8-quinolinylbenzamide

Molecular Formula:

C₂₅H₁₉N₃O₃

Molecular Weight:

409.4

CAS Number

1127442-82-3

Purity:

≥98%

Storage Conditions:

Product should be kept at -20°C.

References:

Huang, S. M. A., Mishina, Y. M., Liu, S., Cheung, A., Stegmeier, F., Michaud, G. A., ... & Cong, F. (2009). Tankyrase inhibition stabilizes axin and antagonizes Wnt signalling.Nature,461(7264), 614-620.

Chen, B., Dodge, M. E., Tang, W., Lu, J., Ma, Z., Fan, C. W., ... & Lum, L. (2009). Small molecule–mediated disruption of Wnt-dependent signaling in tissue regeneration and cancer.Nature chemical biology,5(2), 100-107.

Bao, R., Christova, T., Song, S., Angers, S., Yan, X., & Attisano, L. (2012). Inhibition of tankyrases induces Axin stabilization and blocks Wnt signalling in breast cancer cells.