Recombinant Human BMP-10
货号：120-40-10,120-40-100,120-40-1000,120-40-2,120-40-250,120-40-500
规格：10ug,100ug,1mg,2ug,250ug,500ug
价格：1568,9171,36743,643,16052,23843
产品类型：细胞因子添加物
品牌：PeproTech
| 产品描述：Bone morphogenetic proteins (BMPs) constitute a subfamily within the TGF-β superfamily of structurally related signaling proteins. Members of this superfamily are widely distributed throughout the body and are involved in diverse physiological processes during both pre- and postnatal life. BMP-10 plays a crucial role in the development of the embryonic heart by acting to stimulate and maintain cardiomyocyte proliferation. It can signal through various receptor complexes usually containing BMPR-1A, BMPR-1B, ALK1, ALK3, or ALK6. The interaction of BMP-10 with its specific receptors can induce signaling initiated by the phosphorylation of SMAD transcription factors, including SMAD1, SMAD5, or SMAD8, but can also induce SMAD independent processes. BMP-10 is structurally related to BMP-9, and both can inhibit endothelial cell proliferation and migration. Recombinant Human BMP-10 is a 24.4 kDa homodimeric disulfide-linked protein consisting of two 108 amino acid subunits, which correspond to amino acid residues 317 to 424 of the full-length BMP-10 precursor.来源:HEK293 cells别名:Bone Morphogenetic Protein-10氨基酸序列:NAKGNYCKRT PLYIDFKEIG WDSWIIAPPG YEAYECRGVC NYPLAEHLTP TKHAIIQALV HLKNSQKASK ACCVPTKLEP ISILYLDKGV VTYKFKYEGM AVSECGCR纯度:≥ 95% by SDS-PAGE gel and HPLC analyses.生物活性:Determined by its ability to induce alkaline phosphatase production by ATDC-5 cells. The expectedED50for this effect is 4.0-6.0 ng/ml.Calculated Molecular Weight:24.4 kDaAccession Number:O95393Gene ID:27302交叉反应:Human |
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